HM10_CAEEL
ID HM10_CAEEL Reviewed; 344 AA.
AC P41935;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Homeobox protein ceh-10;
GN Name=ceh-10 {ECO:0000312|WormBase:W03A3.1};
GN ORFNames=W03A3.1 {ECO:0000312|WormBase:W03A3.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Bristol N2;
RX PubMed=7789259; DOI=10.1242/dev.121.5.1253;
RA Svendsen P.C., McGhee J.D.;
RT "The C. elegans neuronally expressed homeobox gene ceh-10 is closely
RT related to genes expressed in the vertebrate eye.";
RL Development 121:1253-1262(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-201.
RX PubMed=1978282; DOI=10.1093/nar/18.20.6101;
RA Hawkins N.C., McGhee J.D.;
RT "Homeobox containing genes in the nematode Caenorhabditis elegans.";
RL Nucleic Acids Res. 18:6101-6106(1990).
RN [4]
RP FUNCTION.
RX PubMed=2361334; DOI=10.1002/dvg.1020110107;
RA Manser J., Wood W.B.;
RT "Mutations affecting embryonic cell migrations in Caenorhabditis elegans.";
RL Dev. Genet. 11:49-64(1990).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF ALA-205.
RX PubMed=9475729; DOI=10.1093/genetics/148.1.151;
RA Forrester W.C., Perens E., Zallen J.A., Garriga G.;
RT "Identification of Caenorhabditis elegans genes required for neuronal
RT differentiation and migration.";
RL Genetics 148:151-165(1998).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF 145-GLN--MET-344.
RX PubMed=20501595; DOI=10.1242/dev.040881;
RA Van Buskirk C., Sternberg P.W.;
RT "Paired and LIM class homeodomain proteins coordinate differentiation of
RT the C. elegans ALA neuron.";
RL Development 137:2065-2074(2010).
CC -!- FUNCTION: Required for larval development and for cell fate
CC specification and migration of CAN neurons (PubMed:9475729,
CC PubMed:2361334). Required for generation, or placement, and
CC differentiation of the ALA neuron, and may play a role in ALA axon
CC migration (PubMed:20501595). {ECO:0000269|PubMed:20501595,
CC ECO:0000269|PubMed:2361334, ECO:0000269|PubMed:9475729}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in several neurons including AIY, CEPDL,
CC RID, ALA, RMED, AIN, AVJ and CAN neurons. {ECO:0000269|PubMed:7789259,
CC ECO:0000269|PubMed:9475729}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes severe defects in
CC the ALA neuron in young adults, and when RNAi is begun embryonically,
CC some individuals lack a detectable ALA neuron.
CC {ECO:0000269|PubMed:20501595}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; U19995; AAA93063.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD73324.1; -; Genomic_DNA.
DR EMBL; X52812; CAB57216.1; -; Genomic_DNA.
DR PIR; S13130; S13130.
DR PIR; T34470; T34470.
DR PIR; T37297; T37297.
DR RefSeq; NP_498251.1; NM_065850.1.
DR AlphaFoldDB; P41935; -.
DR SMR; P41935; -.
DR BioGRID; 41036; 1.
DR IntAct; P41935; 1.
DR STRING; 6239.W03A3.1; -.
DR PaxDb; P41935; -.
DR EnsemblMetazoa; W03A3.1.1; W03A3.1.1; WBGene00000435.
DR GeneID; 175811; -.
DR KEGG; cel:CELE_W03A3.1; -.
DR UCSC; W03A3.1; c. elegans.
DR CTD; 175811; -.
DR WormBase; W03A3.1; CE07563; WBGene00000435; ceh-10.
DR eggNOG; KOG0494; Eukaryota.
DR GeneTree; ENSGT00940000168254; -.
DR HOGENOM; CLU_853172_0_0_1; -.
DR InParanoid; P41935; -.
DR OMA; QRMSFAI; -.
DR OrthoDB; 1014909at2759; -.
DR SignaLink; P41935; -.
DR PRO; PR:P41935; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000435; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IMP:WormBase.
DR GO; GO:0040011; P:locomotion; IMP:WormBase.
DR GO; GO:0048666; P:neuron development; IMP:WormBase.
DR GO; GO:0001764; P:neuron migration; IMP:WormBase.
DR GO; GO:0018991; P:oviposition; IMP:WormBase.
DR GO; GO:1904081; P:positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation; IMP:WormBase.
DR GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR023339; CVC.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51496; CVC; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus;
KW Reference proteome.
FT CHAIN 1..344
FT /note="Homeobox protein ceh-10"
FT /id="PRO_0000048986"
FT DOMAIN 196..250
FT /note="CVC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00829"
FT DNA_BIND 136..195
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 97..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 145..344
FT /note="Missing: In gm133; at early larval stage L1, the
FT majority of animals appear to lack both ALA and RID
FT neurons, while others show a single neuron."
FT /evidence="ECO:0000269|PubMed:20501595"
FT MUTAGEN 205
FT /note="A->T: In gm58; larval lethality."
FT /evidence="ECO:0000269|PubMed:9475729"
SQ SEQUENCE 344 AA; 38272 MW; 4A12428A0AA13185 CRC64;
MAVDEMQLAA SMQMSNQMSN SQRMSFAIHE ILGIQGNAYL SHGYCPQGTF LSNQPNFMDI
GSCGVSGFDR QLCGTDSIGN APAPLMYRMP ISTSEVITSE PQTHVSSSSI LSSATTSNSS
GGGSSGGGGK ASKRKKRRHR TIFTQYQIDE LEKAFQDSHY PDIYAREVLA GKTELQEDRI
QVWFQNRRAK WRKTEKTWGK STIMAEYGLY GAMVRHSLPL PETITKSAEA ADPQQSAAPW
LLGMHKKSME AAAHLESVEK CDMSDSDDDD RPVTPPVQRQ VKNEYKPRII EHVQQQAPQH
QSSLNFDTSL VVSSSLSQLH FQDSQMIPNN NASLKLYHDY NNPM
