HM13_CAEEL
ID HM13_CAEEL Reviewed; 202 AA.
AC P17488;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Homeobox protein ceh-13;
GN Name=ceh-13; ORFNames=R13A5.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=10068646; DOI=10.1242/dev.126.7.1537;
RA Brunschwig K., Wittmann C., Schnabel R., Buerglin T.R., Tobler H.,
RA Mueller F.;
RT "Anterior organization of the Caenorhabditis elegans embryo by the labial-
RT like Hox gene ceh-13.";
RL Development 126:1537-1546(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1970877; DOI=10.1093/nar/18.8.2033;
RA Schaller D., Wittmann C., Spicher A., Mueller F., Tobler H.;
RT "Cloning and analysis of three new homeobox genes from the nematode
RT Caenorhabditis elegans.";
RL Nucleic Acids Res. 18:2033-2036(1990).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; X17077; CAA34929.1; -; Genomic_DNA.
DR EMBL; FO080424; CCD63600.1; -; Genomic_DNA.
DR PIR; S09505; S09505.
DR RefSeq; NP_498655.1; NM_066254.5.
DR AlphaFoldDB; P17488; -.
DR SMR; P17488; -.
DR BioGRID; 41277; 1.
DR STRING; 6239.R13A5.5; -.
DR EPD; P17488; -.
DR PaxDb; P17488; -.
DR EnsemblMetazoa; R13A5.5.1; R13A5.5.1; WBGene00000437.
DR GeneID; 176069; -.
DR KEGG; cel:CELE_R13A5.5; -.
DR UCSC; R13A5.5; c. elegans.
DR CTD; 176069; -.
DR WormBase; R13A5.5; CE28767; WBGene00000437; ceh-13.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00970000196673; -.
DR HOGENOM; CLU_096215_0_0_1; -.
DR InParanoid; P17488; -.
DR OMA; QHNTYKW; -.
DR OrthoDB; 1386702at2759; -.
DR PhylomeDB; P17488; -.
DR PRO; PR:P17488; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000437; Expressed in embryonic cell and 34 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IMP:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..202
FT /note="Homeobox protein ceh-13"
FT /id="PRO_0000048988"
FT DNA_BIND 114..173
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 60..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 202 AA; 22937 MW; 1F24DA06252FB295 CRC64;
MSSTECYGAP PHNYYQDWPT THSYYPSVPS SYSPLNHHPA DIWAAHPSNY IMGNGHVSPP
ATASGLSPPA SRSSNSSAEL PTGVTASQHN TYKWMHTKRS QRPAAPKKKV IDENGTNRTN
FTTHQLTELE KEFHTAKYVN RTRRTEIASN LKLQEAQVKI WFQNRRMKEK KREKEKAFLA
RNTWESNSPT SSCSGEDVKN FK
