ID   HM14A_CHICK             Reviewed;         105 AA.
AC   P12902;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Non-histone chromosomal protein HMG-14A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3384337; DOI=10.1016/0378-1119(88)90532-x;
RA   Dodgson J.B., Browne D.L., Black A.J.;
RT   "Chicken chromosomal protein HMG-14 and HMG-17 cDNA clones: isolation,
RT   characterization and sequence comparison.";
RL   Gene 63:287-295(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=White leghorn;
RX   PubMed=8444343; DOI=10.1016/0378-1119(93)90394-i;
RA   Browne D.L., Dodgson J.B.;
RT   "The gene encoding chicken chromosomal protein HMG-14a is transcribed into
RT   multiple mRNAs.";
RL   Gene 124:199-206(1993).
CC   -!- FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering
CC       the interaction between the DNA and the histone octamer. May be
CC       involved in the process which maintains transcribable genes in a unique
CC       chromatin conformation.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: There are two HMG-14 proteins in chicken: HMG-14A the
CC       major component, and HMG-14B the minor component.
CC   -!- SIMILARITY: Belongs to the HMGN family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M26675; AAA48815.1; -; Genomic_DNA.
DR   EMBL; X63083; CAA44804.1; -; Genomic_DNA.
DR   EMBL; X63084; CAA44804.1; JOINED; Genomic_DNA.
DR   EMBL; X63085; CAA44804.1; JOINED; Genomic_DNA.
DR   EMBL; X63086; CAA44804.1; JOINED; Genomic_DNA.
DR   EMBL; X63087; CAA44804.1; JOINED; Genomic_DNA.
DR   PIR; S22122; NSCHH4.
DR   RefSeq; XP_015134007.1; XM_015278521.1.
DR   RefSeq; XP_015134008.1; XM_015278522.1.
DR   AlphaFoldDB; P12902; -.
DR   STRING; 9031.ENSGALP00000011539; -.
DR   PaxDb; P12902; -.
DR   Ensembl; ENSGALT00000011553; ENSGALP00000011539; ENSGALG00000007131.
DR   GeneID; 422278; -.
DR   KEGG; gga:422278; -.
DR   CTD; 79366; -.
DR   VEuPathDB; HostDB:geneid_422278; -.
DR   eggNOG; ENOG502S5FK; Eukaryota.
DR   GeneTree; ENSGT00950000182802; -.
DR   InParanoid; P12902; -.
DR   OMA; SEQQHCR; -.
DR   OrthoDB; 1635702at2759; -.
DR   PRO; PR:P12902; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000007131; Expressed in colon and 12 other tissues.
DR   ExpressionAtlas; P12902; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR   InterPro; IPR000079; HMGN_fam.
DR   Pfam; PF01101; HMG14_17; 1.
DR   PRINTS; PR00925; NONHISHMG17.
DR   SMART; SM00527; HMG17; 1.
DR   PROSITE; PS00355; HMG14_17; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..105
FT                   /note="Non-histone chromosomal protein HMG-14A"
FT                   /id="PRO_0000206694"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   105 AA;  11357 MW;  0453063E599286BF CRC64;
     MPKRKAPAEG EAKEEPKRRS ARLSAKPAPP KPEPKPKKAA PKKEKAANDK KEDKKAATKG
     KKGAKGKDET KQEDAKEENH SENGDTKTNE APAAEASDDK EAKSE