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ANXA7_XENLA
ID   ANXA7_XENLA             Reviewed;         512 AA.
AC   Q92125;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Annexin A7;
DE   AltName: Full=Annexin VII;
DE   AltName: Full=Annexin-7;
DE   AltName: Full=Synexin;
GN   Name=anxa7; Synonyms=anx7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8670145; DOI=10.1042/bj3160729;
RA   Srivastava M., Zhang-Keck Z.Y., Caohuy H., McPhie P., Pollard H.B.;
RT   "Novel isoforms of synexin in Xenopus laevis: multiple tandem PGQM repeats
RT   distinguish mRNAs in specific adult tissues and embryonic stages.";
RL   Biochem. J. 316:729-735(1996).
CC   -!- FUNCTION: Calcium/phospholipid-binding protein which promotes membrane
CC       fusion and is involved in exocytosis.
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC       and phospholipid.
CC   -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01245, ECO:0000305}.
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DR   EMBL; U16365; AAB18145.1; -; mRNA.
DR   PIR; S70644; S70644.
DR   RefSeq; NP_001081470.1; NM_001088001.1.
DR   AlphaFoldDB; Q92125; -.
DR   SMR; Q92125; -.
DR   GeneID; 397854; -.
DR   CTD; 310; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR018252; Annexin_repeat_CS.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   SMART; SM00335; ANX; 4.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS00223; ANNEXIN_1; 3.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   2: Evidence at transcript level;
KW   Annexin; Calcium; Calcium/phospholipid-binding; Reference proteome; Repeat.
FT   CHAIN           1..512
FT                   /note="Annexin A7"
FT                   /id="PRO_0000067501"
FT   REPEAT          209..279
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          280..351
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          364..436
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          440..511
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REGION          14..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  53314 MW;  70D532D2524388A4 CRC64;
     MSYQYPSGFP GYPGYPGGDP SYPPAAQQAF PGGQFPPAAG GGAFPPASGG GNAPPPGGGY
     PHAGGYPAPG GYPGGMPSYP GAPGFGAPAG GQGYGAPPGA PAYGVPGYGG PGFNAPAGGY
     GAPNAGGFGV PPAGGYGSPG GAPGYGGFSQ PSSQSYGAGG PGQMPGQMPG QMPGQAPSGY
     PSGPAPAQPT PYAAAMTATQ GTIKAAPNFD ALSDAEKLRK AMKGFGTDEK PIDVVANRSN
     DQRQKIQAAF KTAYGKDLIK DLKSELSGNV EELIIALFMP STYYDAWSLY NAMKGAGTQE
     RVLIEILCTR TNSEIRNIVA CYKQEFGREI EKDIRSDTSG HFERLLISIM ARGIVDESQN
     VNMQQAEQDA QRLYQAGEGK LGTDESSFNL VLASRSFPQL KAVAEAYARI SKRDLLSVIG
     REFSGYIEDG LKAVLQCAIN RPLFFRDRLC RSMKGAGTDD STLIRIIVTR SEIDLVQIKQ
     AYVQMYQKSL SAAISSDTSG AYKRMLLAIS GH
 
 
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