ID   HM20B_BOVIN             Reviewed;         317 AA.
AC   Q32L68;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related;
DE            Short=SMARCE1-related protein;
DE   AltName: Full=HMG box-containing protein 20B;
GN   Name=HMG20B; Synonyms=SMARCE1R;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for correct progression through G2 phase of the cell
CC       cycle and entry into mitosis. Required for RCOR1/CoREST mediated
CC       repression of neuronal specific gene promoters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a BHC histone deacetylase complex that contains
CC       HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The
CC       BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
CC       Interacts with the BRCA2 tumor suppressor protein (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC       Chromosome {ECO:0000250}. Note=Localized to condensed chromosomes in
CC       mitosis in conjunction with BRCA2. {ECO:0000250}.
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DR   EMBL; BC109740; AAI09741.1; -; mRNA.
DR   RefSeq; NP_001033143.1; NM_001038054.1.
DR   AlphaFoldDB; Q32L68; -.
DR   SMR; Q32L68; -.
DR   STRING; 9913.ENSBTAP00000011581; -.
DR   PaxDb; Q32L68; -.
DR   PRIDE; Q32L68; -.
DR   Ensembl; ENSBTAT00000011581; ENSBTAP00000011581; ENSBTAG00000008789.
DR   GeneID; 507723; -.
DR   KEGG; bta:507723; -.
DR   CTD; 10362; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008789; -.
DR   eggNOG; KOG0381; Eukaryota.
DR   GeneTree; ENSGT00940000161213; -.
DR   HOGENOM; CLU_060006_2_0_1; -.
DR   InParanoid; Q32L68; -.
DR   OMA; NIDRYMH; -.
DR   OrthoDB; 1458939at2759; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000008789; Expressed in digestive system secreted substance and 106 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Chromatin regulator; Chromosome; Coiled coil; DNA-binding;
KW   Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN           1..317
FT                   /note="SWI/SNF-related matrix-associated actin-dependent
FT                   regulator of chromatin subfamily E member 1-related"
FT                   /id="PRO_0000281860"
FT   DNA_BIND        70..138
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..257
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        35..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         160
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P0W2"
FT   CROSSLNK        31
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P0W2"
SQ   SEQUENCE   317 AA;  35829 MW;  E1A34C1F58D17008 CRC64;
     MSHGPKQPGA ASAPASGKAP GQHGSFVVAV KQERGEGPRA GEKGSHEEEP VKKRGWPKGK
     KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI TKMLGAEWSK LQPAEKQRYL
     DEAEREKQQY MKELRAYQQS EAYKMCAEKI QEKKIKKEDS SSGLMNTLLN GHKGGDCDGF
     STFDVPIFTE EFLDQNKARE AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL
     EERRTLALQQ QLQAVRQALT ASFASLPVPG TGETPTLSTL DFYMARLHGA IERDPAQHEK
     LIVRIKEILA QVASEHL