ID   HM23_CAEEL              Reviewed;         305 AA.
AC   P34663; Q9TYD8;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Homeobox protein ceh-23;
GN   Name=ceh-23; ORFNames=ZK652.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-305.
RX   PubMed=8101474; DOI=10.1016/0092-8674(93)90292-x;
RA   Wang B.B., Mueller-Immergluck M.M., Austin J., Robinson N.T.,
RA   Chisholm A.D., Kenyon C.;
RT   "A homeotic gene cluster patterns the anteroposterior body axis of C.
RT   elegans.";
RL   Cell 74:29-42(1993).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; FO080278; CCD62550.1; -; Genomic_DNA.
DR   EMBL; L19249; AAC37167.1; -; mRNA.
DR   PIR; S44907; S44907.
DR   RefSeq; NP_498700.1; NM_066299.3.
DR   AlphaFoldDB; P34663; -.
DR   SMR; P34663; -.
DR   BioGRID; 41304; 11.
DR   IntAct; P34663; 11.
DR   STRING; 6239.ZK652.5; -.
DR   PaxDb; P34663; -.
DR   EnsemblMetazoa; ZK652.5.1; ZK652.5.1; WBGene00000446.
DR   GeneID; 176096; -.
DR   KEGG; cel:CELE_ZK652.5; -.
DR   UCSC; ZK652.5; c. elegans.
DR   CTD; 176096; -.
DR   WormBase; ZK652.5; CE00451; WBGene00000446; ceh-23.
DR   eggNOG; KOG0843; Eukaryota.
DR   HOGENOM; CLU_078608_0_0_1; -.
DR   InParanoid; P34663; -.
DR   OMA; YSETNME; -.
DR   OrthoDB; 1594142at2759; -.
DR   PhylomeDB; P34663; -.
DR   SignaLink; P34663; -.
DR   PRO; PR:P34663; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000446; Expressed in larva.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase.
DR   GO; GO:1904081; P:positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation; IMP:WormBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Homeobox protein ceh-23"
FT                   /id="PRO_0000048993"
FT   DNA_BIND        211..270
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          113..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..305
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   305 AA;  33261 MW;  C9A0CE8B6489362E CRC64;
     MDTHLPFQTL PVSTPLPVSS SSLTDVLQTI AALQACPTSC IPSTSTGMLS PNLPFSATIP
     RVNLFPPSQP ANSLILPTIP AQPFIPNPSL LQANPSAVEA LANALFATTS RRASCPEPPA
     SSQATVTLQV PSTGSPERRR YSETNMEVLL REQLAQLMPP TSQLPGMPGC YYQHVPAAGT
     SGIQGSLDAA LMGAVPLAMN SMAHSRRAAN HRKARTIYGT TQTQQLEDMF KGQMYVVGAE
     RENLAQRLGL SPSQVRIWFQ NRRSKHRRKQ QEEQQSTTLE EKSEEIGKDE EEDDEEDEDD
     VKVLN