ID   HM24_CAEBR              Reviewed;         293 AA.
AC   O17319; A8XCX2; Q61FW0;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 3.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Homeobox protein ceh-24;
GN   Name=ceh-24 {ECO:0000312|WormBase:CBG11477};
GN   ORFNames=CBG11477 {ECO:0000312|WormBase:CBG11477};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=9425137; DOI=10.1242/dev.125.3.421;
RA   Harfe B.D., Fire A.;
RT   "Muscle and nerve-specific regulation of a novel NK-2 class homeodomain
RT   factor in Caenorhabditis elegans.";
RL   Development 125:421-429(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Probable transcriptional regulator that is required in neural
CC       development for the normal formation of sublateral cholinergic motor
CC       neuron processes. Plays a role in regulating the expression of
CC       acetylcholine transporter protein unc-17 in the sublateral processes.
CC       In particular, it is required in sublateral motor neurons for a left-
CC       right turning behavior that occurs during the lethargus phase of the
CC       normal sleep process called 'flipping'. During 'flipping' animals
CC       rotate 180 degrees about their longitudinal axis.
CC       {ECO:0000250|UniProtKB:Q9NLC2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in the 8 vulval muscles, 8-10 ventral
CC       neurons in the head and in the most posterior pharyngeal muscle cell,
CC       m8. {ECO:0000269|PubMed:9425137}.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR   EMBL; AF026057; AAB86603.1; -; Genomic_DNA.
DR   EMBL; HE600908; CAP30490.3; -; Genomic_DNA.
DR   AlphaFoldDB; O17319; -.
DR   SMR; O17319; -.
DR   STRING; 6238.CBG11477; -.
DR   WormBase; CBG11477; CBP42339; WBGene00032588; Cbr-ceh-24.
DR   eggNOG; KOG0842; Eukaryota.
DR   HOGENOM; CLU_918976_0_0_1; -.
DR   InParanoid; O17319; -.
DR   OMA; SAINHQF; -.
DR   OrthoDB; 1450195at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..293
FT                   /note="Homeobox protein ceh-24"
FT                   /id="PRO_0000048994"
FT   DNA_BIND        144..203
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..244
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        107
FT                   /note="Q -> QG (in Ref. 1; AAB86603)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        134
FT                   /note="A -> R (in Ref. 1; AAB86603)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        218
FT                   /note="C -> S (in Ref. 1; AAB86603)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="G -> GNFQ (in Ref. 1; AAB86603)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   293 AA;  32371 MW;  CC400756675C3A0A CRC64;
     MSEKESPSPQ HKKDEVVDDT EQETKDSEDD ATKKMKIKEG SKFTMNSILS PLESLARVQQ
     QLLKMAAAQS GFGGNGSGGN GANGFPYPAR FATNCFSGPF PGYNGSQNWY NGNDARFAAA
     AALLPCAIDP VRSAINHQFS MSQRRKRRVL FSQAQVYELE RRFKQAKYLT APEREQLANS
     IRLTPTQVKI WFQNHRYKCK RQEKEKAMSG LGHGDDGCSP PPGDDDDDDD KYSIEMDDKD
     DEEEDGAKPM LKSNGVFGLP YPSPANAAAA AAAAAFNFQF GAQGPNPAYF MRW