HM24_CAEEL
ID HM24_CAEEL Reviewed; 299 AA.
AC Q9NLC2; O17318;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Homeobox protein ceh-24;
GN Name=ceh-24 {ECO:0000312|WormBase:F55B12.1};
GN ORFNames=F55B12.1 {ECO:0000312|WormBase:F55B12.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=9425137; DOI=10.1242/dev.125.3.421;
RA Harfe B.D., Fire A.;
RT "Muscle and nerve-specific regulation of a novel NK-2 class homeodomain
RT factor in Caenorhabditis elegans.";
RL Development 125:421-429(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=28244369; DOI=10.7554/elife.24846;
RA Schwarz J., Bringmann H.;
RT "Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron
RT control of left-right turning during sleep.";
RL Elife 6:0-0(2017).
CC -!- FUNCTION: Probable transcriptional regulator that is required in neural
CC development for the normal formation of sublateral cholinergic motor
CC neuron processes. Plays a role in regulating the expression of
CC acetylcholine transporter protein unc-17 in the sublateral processes.
CC In particular, it is required in sublateral motor neurons for a left-
CC right turning behavior that occurs during the lethargus phase of the
CC normal sleep process called 'flipping'. During 'flipping' animals
CC rotate 180 degrees about their longitudinal axis.
CC {ECO:0000269|PubMed:28244369}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the 8 vulval muscles, 8-10 ventral
CC neurons in the head and in the most posterior pharyngeal muscle cell,
CC m8 (PubMed:9425137). Expressed in SIA, SIB and SMB sublateral motor
CC neurons, and in muscles of the pharynx and vulva (PubMed:28244369).
CC {ECO:0000269|PubMed:28244369, ECO:0000269|PubMed:9425137}.
CC -!- DEVELOPMENTAL STAGE: First expressed in the m8 pharyngeal muscle cell
CC and in ventral head neurons in embryos 400 minutes after the first cell
CC cleavage. {ECO:0000269|PubMed:9425137}.
CC -!- DISRUPTION PHENOTYPE: Normal growth, coordination, egg-laying, mating,
CC chemotaxis, pharyngeal pumping and VC neuron synapses as in wild-type
CC animals (PubMed:9425137). Abnormal sleep behavior with mutant larvae
CC displaying a reduced, if not absent, type of turning behavior called
CC 'flipping' (PubMed:28244369). Irregular formation and extension of
CC sublateral motor neuron processes (PubMed:28244369).
CC {ECO:0000269|PubMed:28244369, ECO:0000269|PubMed:9425137}.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR EMBL; AF026056; AAB81844.1; -; mRNA.
DR EMBL; Z79757; CAB60999.1; -; Genomic_DNA.
DR PIR; T22698; T22698.
DR PIR; T37251; T37251.
DR RefSeq; NP_506419.3; NM_074018.4.
DR AlphaFoldDB; Q9NLC2; -.
DR SMR; Q9NLC2; -.
DR BioGRID; 44891; 4.
DR IntAct; Q9NLC2; 3.
DR STRING; 6239.F55B12.1; -.
DR PaxDb; Q9NLC2; -.
DR EnsemblMetazoa; F55B12.1.1; F55B12.1.1; WBGene00000447.
DR GeneID; 179877; -.
DR KEGG; cel:CELE_F55B12.1; -.
DR UCSC; F55B12.1; c. elegans.
DR CTD; 179877; -.
DR WormBase; F55B12.1; CE25006; WBGene00000447; ceh-24.
DR eggNOG; KOG0842; Eukaryota.
DR GeneTree; ENSGT00940000168126; -.
DR HOGENOM; CLU_918976_0_0_1; -.
DR InParanoid; Q9NLC2; -.
DR OMA; SAINHQF; -.
DR OrthoDB; 1450195at2759; -.
DR PhylomeDB; Q9NLC2; -.
DR SignaLink; Q9NLC2; -.
DR PRO; PR:Q9NLC2; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000447; Expressed in organism subdivision and 9 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:WormBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; ISS:WormBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..299
FT /note="Homeobox protein ceh-24"
FT /id="PRO_0000048995"
FT DNA_BIND 150..209
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..250
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 85
FT /note="A -> E (in Ref. 1; AAB81844)"
FT /evidence="ECO:0000305"
FT CONFLICT 276..277
FT /note="AA -> R (in Ref. 1; AAB81844)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 33077 MW; 6D08AB8E8B3A5AFF CRC64;
MSEKETPSPV LDVKKEKNEE TGIDEEKSSE DDCSKRSKVK SNPSKFSVNS ILSPLESLVR
VQQQLLKMAA SKSGTPGTNA GVPGAFPYGP GRLPGNYFAG PFPGYSGAQP NWYNGNDPRF
AAAAALLPCS IDPVRSAINH QFSMSSMSQR RKRRVLFSQA QVYELERRFK QAKYLTAPER
EQLANSIRLT PTQVKIWFQN HRYKCKRQEK EKAMSGLGHS EDGSSPPPDN DDDDDKYSIE
MDDKDDEEEE ESEKPVLKPS GVFGLPYPPN AAAAAAAAAA AFNFPFAAQG PNPAYYMRW
