ID   HM30_CAEBR              Reviewed;         233 AA.
AC   A8XJD0;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Homeobox protein ceh-30 {ECO:0000250|UniProtKB:Q22909};
GN   Name=ceh-30 {ECO:0000312|EMBL:CAP32755.1}; ORFNames=CBG14125;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP32755.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP32755.1};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Cell-type specific anti-apoptotic transcription factor
CC       required for the sexually dimorphic survival of the male-specific CEM
CC       (cephalic male) sensory neurons during sex determination. In
CC       hermaphrodites, the homologous cells undergo programmed cell death due
CC       to transcriptional repression of ceh-30 by tra-1, the terminal
CC       regulator in the sex determination pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q22909}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q22909,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; HE600983; CAP32755.1; -; Genomic_DNA.
DR   RefSeq; XP_002644317.1; XM_002644271.1.
DR   AlphaFoldDB; A8XJD0; -.
DR   SMR; A8XJD0; -.
DR   STRING; 6238.CBG14125; -.
DR   EnsemblMetazoa; CBG14125.1; CBG14125.1; WBGene00034724.
DR   GeneID; 8586312; -.
DR   KEGG; cbr:CBG_14125; -.
DR   CTD; 8586312; -.
DR   WormBase; CBG14125; CBP09847; WBGene00034724; Cbr-ceh-30.
DR   eggNOG; KOG0488; Eukaryota.
DR   HOGENOM; CLU_102319_0_0_1; -.
DR   InParanoid; A8XJD0; -.
DR   OMA; SPYWANY; -.
DR   OrthoDB; 1449832at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0007399; P:nervous system development; IEA:EnsemblMetazoa.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Sexual differentiation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..233
FT                   /note="Homeobox protein ceh-30"
FT                   /id="PRO_0000358601"
FT   DNA_BIND        88..147
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          50..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   233 AA;  26029 MW;  AF9E10B2385E35C0 CRC64;
     MSLLDPRQFL LPAFYLDPST QAFLTQAVSN HKLGTASSFR ISDILEPSPN NSTYSHDLDP
     SPQSVRSDLS TSPRASSPDR NSPMSKKSRK ARTIFTDKQL QELENTFEKQ KYLSVQDRMD
     LAHRMGLSDT QVKTWYQNRR TKWKRQATSG MDLLSEPGNL SAVQNLIRSS PYWANYITAL
     PMGGQMGQMP MMGLPMPMIV PPAQHFQATS SSNSPSTHKS SESPQLDVSS NSD