ID   HM30_CAEEL              Reviewed;         237 AA.
AC   Q22909;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Homeobox protein ceh-30;
GN   Name=ceh-30; ORFNames=C33D12.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=18056428; DOI=10.1101/gad.1607007;
RA   Schwartz H.T., Horvitz H.R.;
RT   "The C. elegans protein CEH-30 protects male-specific neurons from
RT   apoptosis independently of the Bcl-2 homolog CED-9.";
RL   Genes Dev. 21:3181-3194(2007).
CC   -!- FUNCTION: Cell-type specific anti-apoptotic transcription factor
CC       required for the sexually dimorphic survival of the male-specific CEM
CC       (cephalic male) sensory neurons during sex determination. In
CC       hermaphrodites, the homologous cells undergo programmed cell death due
CC       to transcriptional repression of ceh-30 by tra-1, the terminal
CC       regulator in the sex determination pathway.
CC       {ECO:0000269|PubMed:18056428}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000269|PubMed:18056428}.
CC   -!- TISSUE SPECIFICITY: Expressed transiently in embryonic CEM (cephalic
CC       male) sensory neurons. {ECO:0000269|PubMed:18056428}.
CC   -!- DISRUPTION PHENOTYPE: Worms undergo programmed cell death of CEM
CC       (cephalic male) sensory neurons in males.
CC       {ECO:0000269|PubMed:18056428}.
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DR   EMBL; FO080757; CCD66474.1; -; Genomic_DNA.
DR   PIR; T25610; T25610.
DR   RefSeq; NP_508524.2; NM_076123.3.
DR   AlphaFoldDB; Q22909; -.
DR   SMR; Q22909; -.
DR   BioGRID; 56122; 12.
DR   IntAct; Q22909; 11.
DR   STRING; 6239.C33D12.7; -.
DR   EPD; Q22909; -.
DR   PaxDb; Q22909; -.
DR   PRIDE; Q22909; -.
DR   EnsemblMetazoa; C33D12.7.1; C33D12.7.1; WBGene00000451.
DR   EnsemblMetazoa; C33D12.7.2; C33D12.7.2; WBGene00000451.
DR   GeneID; 191620; -.
DR   KEGG; cel:CELE_C33D12.7; -.
DR   UCSC; C33D12.7; c. elegans.
DR   CTD; 191620; -.
DR   WormBase; C33D12.7; CE42074; WBGene00000451; ceh-30.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000169370; -.
DR   HOGENOM; CLU_102319_0_0_1; -.
DR   InParanoid; Q22909; -.
DR   OMA; SPYWANY; -.
DR   OrthoDB; 1449832at2759; -.
DR   PhylomeDB; Q22909; -.
DR   SignaLink; Q22909; -.
DR   PRO; PR:Q22909; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000451; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IMP:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Sexual differentiation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..237
FT                   /note="Homeobox protein ceh-30"
FT                   /id="PRO_0000048996"
FT   DNA_BIND        95..154
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          49..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   237 AA;  26131 MW;  52DFF67EE59ED398 CRC64;
     MSLLDPRQFL LPAFYLDPTT QALLAQAAST SPCNKISSSS SFRISDILEQ SPNNSSHSND
     HDPSPQSIKS DFSTSPRASS PGGDRMGSPG SCKKSRKART IFTDKQLQEL ENTFEKQKYL
     SVQDRMDLAH RMGLTDTQVK TWYQNRRTKW KRQATSGMDL LSEPGNLSAV QNLIRSSPYW
     ANYITALPMG TQLPMMGLPM SMIVPPAHAF QPSSSSNSPS THISSESPQL DVSSNSE