ID   HM33_CAEEL              Reviewed;         261 AA.
AC   Q94166;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Homeobox protein ceh-33;
GN   Name=ceh-33; ORFNames=C10G8.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC       {ECO:0000305}.
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DR   EMBL; FO080497; CCD64165.1; -; Genomic_DNA.
DR   PIR; G89046; G89046.
DR   RefSeq; NP_504420.1; NM_072019.1.
DR   AlphaFoldDB; Q94166; -.
DR   SMR; Q94166; -.
DR   BioGRID; 56124; 1.
DR   DIP; DIP-25570N; -.
DR   IntAct; Q94166; 1.
DR   STRING; 6239.C10G8.7; -.
DR   PaxDb; Q94166; -.
DR   EnsemblMetazoa; C10G8.7.1; C10G8.7.1; WBGene00000454.
DR   GeneID; 191622; -.
DR   KEGG; cel:CELE_C10G8.7; -.
DR   UCSC; C10G8.7; c. elegans.
DR   CTD; 191622; -.
DR   WormBase; C10G8.7; CE08078; WBGene00000454; ceh-33.
DR   eggNOG; KOG0775; Eukaryota.
DR   HOGENOM; CLU_046914_0_1_1; -.
DR   InParanoid; Q94166; -.
DR   OMA; RDNANIW; -.
DR   OrthoDB; 1061244at2759; -.
DR   PhylomeDB; Q94166; -.
DR   PRO; PR:Q94166; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00000454; Expressed in larva and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:WormBase.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031701; SIX1_SD.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..261
FT                   /note="Homeobox protein ceh-33"
FT                   /id="PRO_0000048999"
FT   DNA_BIND        133..192
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   261 AA;  30711 MW;  82438B2842880E2E CRC64;
     MQLNSSSFHP HHFTCDTTRY SEEQVACICE ALSNDARKLS QFVWTVLERD EMRNNQYILK
     AQAFLAFHSN NFKELYRIIE SHHFASEHHL PLQEWWLNAH YHEAEKIRGR QLGAVGKYRI
     RRKYPLPRTI WDGEETSYCF RDKSRVLLRD WYCRNSYPSP REKRELAEKT HLTVTQVSNW
     FKNRRQRDRA GVPEPKDCLK DISEEEDLKL IRKTASKLSN SFHNPSDLSS YSAAAAAATF
     PGFYMNYNDM MIGAGTSYQS L