HM39_CAEEL
ID HM39_CAEEL Reviewed; 399 AA.
AC Q22812;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Homeobox protein ceh-39;
GN Name=ceh-39 {ECO:0000312|WormBase:T26C11.7};
GN ORFNames=T26C11.7 {ECO:0000312|WormBase:T26C11.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP DISRUPTION PHENOTYPE, AND MUTAGENESIS OF 1-MET--LYS-102.
RX PubMed=17720939; DOI=10.1534/genetics.106.061812;
RA Gladden J.M., Meyer B.J.;
RT "A ONECUT homeodomain protein communicates X chromosome dose to specify
RT Caenorhabditis elegans sexual fate by repressing a sex switch gene.";
RL Genetics 177:1621-1637(2007).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=23666922; DOI=10.1101/gad.217026.113;
RA Farboud B., Nix P., Jow M.M., Gladden J.M., Meyer B.J.;
RT "Molecular antagonism between X-chromosome and autosome signals determines
RT nematode sex.";
RL Genes Dev. 27:1159-1178(2013).
CC -!- FUNCTION: Transciptional regulator which is involved in the sex
CC determination and X chromosome dosage compensation pathways
CC (PubMed:23666922, PubMed:17720939). Directly binds to 5'-ATTGAT-3'
CC sites in the promoter of sex-determining factor xol-1 to negatively
CC regulate its expression and promote hermaphrodite development
CC (PubMed:23666922, PubMed:17720939). Associates with condensed DNA
CC during mitosis (PubMed:17720939). {ECO:0000269|PubMed:17720939,
CC ECO:0000269|PubMed:23666922}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:17720939,
CC ECO:0000305|PubMed:23666922}. Chromosome {ECO:0000269|PubMed:17720939}.
CC Note=During mitosis, localizes to metaphase and anaphase chromosomes
CC (PubMed:17720939). In the hermaphrodite gonads, localizes to the
CC nucleus from late pachytene to diakinesis (PubMed:17720939). Localizes
CC to condensed diakinetic chromosomes (PubMed:17720939).
CC {ECO:0000269|PubMed:17720939}.
CC -!- TISSUE SPECIFICITY: Expressed in hermaphrodite gonads.
CC {ECO:0000269|PubMed:17720939}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos (PubMed:17720939). First
CC expressed in the 2 cell stage, with expression increasing at the 8-cell
CC stage, but subsequently decreasing by the 150-cell stage and almost
CC abolished by the 200-cell stage (PubMed:17720939).
CC {ECO:0000269|PubMed:17720939}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in viable
CC hermaphrodites as in wild-type. {ECO:0000269|PubMed:17720939}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
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DR EMBL; FO080541; CCD64529.1; -; Genomic_DNA.
DR PIR; T28913; T28913.
DR RefSeq; NP_508342.1; NM_075941.4.
DR AlphaFoldDB; Q22812; -.
DR SMR; Q22812; -.
DR BioGRID; 45452; 2.
DR IntAct; Q22812; 2.
DR STRING; 6239.T26C11.7; -.
DR PaxDb; Q22812; -.
DR EnsemblMetazoa; T26C11.7.1; T26C11.7.1; WBGene00000460.
DR GeneID; 180505; -.
DR KEGG; cel:CELE_T26C11.7; -.
DR UCSC; T26C11.7; c. elegans.
DR CTD; 180505; -.
DR WormBase; T26C11.7; CE05026; WBGene00000460; ceh-39.
DR eggNOG; KOG2252; Eukaryota.
DR GeneTree; ENSGT00950000183103; -.
DR HOGENOM; CLU_691242_0_0_1; -.
DR InParanoid; Q22812; -.
DR PhylomeDB; Q22812; -.
DR PRO; PR:Q22812; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000460; Expressed in embryo and 4 other tissues.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:WormBase.
DR GO; GO:0043073; C:germ cell nucleus; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0007538; P:primary sex determination; IGI:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR Pfam; PF02376; CUT; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51042; CUT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..399
FT /note="Homeobox protein ceh-39"
FT /id="PRO_0000202410"
FT DNA_BIND 205..291
FT /note="CUT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT DNA_BIND 315..374
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 32..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 1..102
FT /note="Missing: In y414; hermaphrodites are viable as in
FT wild-type."
FT /evidence="ECO:0000269|PubMed:17720939"
SQ SEQUENCE 399 AA; 44331 MW; DC5AAD2EE0C8E87F CRC64;
MDFSNTYRNY GEVVDFPEDF LSDYVPTVKS EPEPAAIAPS VCEPPISTTR NYGTDFGRAS
SMCGSSSSSS SSSYSSGSSP NYLTENGGDT EEPRFEELVS RKMSFDSENV AQVSNQMDYA
RDTYADSRIP FASIDSNDAL LPYPVNNYVA ALPVPVPAKK SRGRTAPRTP KSLETSKPGR
GVKRPASKEI DAKDLGIGDL SAHMNRQIGD DEELDTQLIA HRILDELKEQ CIPQASLAVK
VLGRSQGTLS DLLRKPKPWG IMKNGRGTFQ RMANWLDLDP VVRRALCFMK KEDVARITGM
AEPTPAKRAR QTTPSDERIR RFTFTQTQLD SLHTVFQQQD RPNREMQQAL SATLKLNRST
VGNFFMNARR RLPKAAPVSQ NLVAEHAIDH NQPGPSHHY
