HM40_CAEEL
ID HM40_CAEEL Reviewed; 329 AA.
AC Q19503;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Homeobox protein ceh-40;
GN Name=ceh-40; ORFNames=F17A2.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=12399316; DOI=10.1242/dev.129.22.5255;
RA Van Auken K., Weaver D., Robertson B., Sundaram M., Saldi T., Edgar L.,
RA Elling U., Lee M., Boese Q., Wood W.B.;
RT "Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs
RT CEH-20 and CEH-40 in C. elegans embryogenesis.";
RL Development 129:5255-5268(2002).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=23788625; DOI=10.1101/gad.217224.113;
RA Doitsidou M., Flames N., Topalidou I., Abe N., Felton T., Remesal L.,
RA Popovitchenko T., Mann R., Chalfie M., Hobert O.;
RT "A combinatorial regulatory signature controls terminal differentiation of
RT the dopaminergic nervous system in C. elegans.";
RL Genes Dev. 27:1391-1405(2013).
CC -!- FUNCTION: Plays a role in regulating gene expression in dopaminergic
CC neurons, acting redundantly with homeobox protein ceh-20 in head
CC neurons (PubMed:23788625). May activate dopamine pathway genes in
CC concert with ETS domain-containing protein ast-1, and homeobox proteins
CC ceh-43 and ceh-20 (PubMed:23788625). {ECO:0000269|PubMed:23788625}.
CC -!- INTERACTION:
CC Q19503; Q9N5D6: unc-62; NbExp=4; IntAct=EBI-319764, EBI-319775;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in head dopaminergic neurons.
CC {ECO:0000269|PubMed:23788625}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos.
CC {ECO:0000269|PubMed:12399316}.
CC -!- DISRUPTION PHENOTYPE: Worms show no phenotype but, when also lacking
CC ceh-20, incompletely penetrant embryonic lethality is observed.
CC {ECO:0000269|PubMed:12399316}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000305}.
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DR EMBL; BX284606; CAA92154.1; -; Genomic_DNA.
DR PIR; T21038; T21038.
DR RefSeq; NP_510060.1; NM_077659.1.
DR AlphaFoldDB; Q19503; -.
DR SMR; Q19503; -.
DR BioGRID; 56126; 11.
DR DIP; DIP-27213N; -.
DR IntAct; Q19503; 9.
DR STRING; 6239.F17A2.5; -.
DR EPD; Q19503; -.
DR PaxDb; Q19503; -.
DR EnsemblMetazoa; F17A2.5.1; F17A2.5.1; WBGene00000461.
DR GeneID; 191624; -.
DR KEGG; cel:CELE_F17A2.5; -.
DR UCSC; F17A2.5; c. elegans.
DR CTD; 191624; -.
DR WormBase; F17A2.5; CE03215; WBGene00000461; ceh-40.
DR eggNOG; KOG0774; Eukaryota.
DR HOGENOM; CLU_041153_1_0_1; -.
DR InParanoid; Q19503; -.
DR OMA; YNPEMMA; -.
DR OrthoDB; 804740at2759; -.
DR PhylomeDB; Q19503; -.
DR SignaLink; Q19503; -.
DR PRO; PR:Q19503; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000461; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR005542; PBX.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..329
FT /note="Homeobox protein ceh-40"
FT /id="PRO_0000049003"
FT DOMAIN 3..186
FT /note="PBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT DNA_BIND 187..249
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 10..90
FT /note="PBC-A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 93..186
FT /note="PBC-B"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT REGION 248..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 38223 MW; A728E6AC8DCD88D8 CRC64;
MSEASKSIMD LLSEVVKITD MTMDNEAVNK LKPQIKINPF YRAVQDVLVE QKSKIDLSTK
MMKDLEAQEN DERLDTMLKA EGVAGPDDSL LRIQEAAGTD QYEYRQQLLK VRRELENETK
AFDKHCKKWC EYVEDVLQQQ GEFRPITQQS TEKFMNKMSG KFNKVCFVLK QTACEEVIQL
KKRYLDARRK RRNFSKTSTE ILNEYFLANI NHPYPSEEVK QALAMQCNIS VAQVSNWFGN
KRIRYKKTMA KNEDERRENR KPEDRPPPGA PGAPYSLVPN AFAGMMNPYQ MMLPGHQFPI
GVAPFNFSMY NPEMMAQYQQ SLQNPNQTR
