ID   HMA2_HELTR              Reviewed;          60 AA.
AC   P17138;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Homeobox protein HTR-A2;
DE   Flags: Fragment;
OS   Helobdella triserialis (Leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1970867; DOI=10.1093/nar/18.7.1908;
RA   Wedeen C.J., Kostriken R.G., Matsumura I., Weisblat D.A.;
RT   "Evidence for a new family of evolutionarily conserved homeobox genes.";
RL   Nucleic Acids Res. 18:1908-1908(1990).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; X51752; CAA36041.1; -; Genomic_DNA.
DR   PIR; S09227; S09227.
DR   AlphaFoldDB; P17138; -.
DR   SMR; P17138; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..>60
FT                   /note="Homeobox protein HTR-A2"
FT                   /id="PRO_0000049008"
FT   DNA_BIND        1..60
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         60
SQ   SEQUENCE   60 AA;  7616 MW;  74147F9C6D3814F4 CRC64;
     NKRTRTAYSR SQLFELEKEF HFDKYISRPR RVELASSLNL TERHIKIWFQ NRRMKWKKME