ID   ANXA8_RABIT             Reviewed;         327 AA.
AC   O97529;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Annexin A8;
DE   AltName: Full=Annexin VIII;
DE   AltName: Full=Annexin-8;
GN   Name=ANXA8;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cheng W., Tsao F.H.C.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is an anticoagulant protein that acts as an
CC       indirect inhibitor of the thromboplastin-specific complex, which is
CC       involved in the blood coagulation cascade. {ECO:0000250}.
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC       and phospholipid. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01245, ECO:0000305}.
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DR   EMBL; AF012745; AAD01508.1; -; mRNA.
DR   RefSeq; NP_001075488.1; NM_001082019.1.
DR   AlphaFoldDB; O97529; -.
DR   SMR; O97529; -.
DR   STRING; 9986.ENSOCUP00000012199; -.
DR   GeneID; 100008655; -.
DR   KEGG; ocu:100008655; -.
DR   CTD; 653145; -.
DR   eggNOG; KOG0819; Eukaryota.
DR   InParanoid; O97529; -.
DR   OrthoDB; 856254at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR018252; Annexin_repeat_CS.
DR   InterPro; IPR037104; Annexin_sf.
DR   InterPro; IPR009115; ANX8.
DR   PANTHER; PTHR10502:SF133; PTHR10502:SF133; 1.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   PRINTS; PR01808; ANNEXINVIII.
DR   SMART; SM00335; ANX; 4.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS00223; ANNEXIN_1; 4.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   2: Evidence at transcript level;
KW   Annexin; Blood coagulation; Calcium; Calcium/phospholipid-binding;
KW   Hemostasis; Metal-binding; Reference proteome; Repeat.
FT   CHAIN           1..327
FT                   /note="Annexin A8"
FT                   /id="PRO_0000231029"
FT   REPEAT          21..92
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          93..164
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          177..249
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          253..324
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   BINDING         266
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         268
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         270
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         310
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   327 AA;  36680 MW;  1815B77B6BE50AB7 CRC64;
     MAWWKAWVEQ EGVTVKGSPH FNPVPDAETL YKAMKGIGTN EQAIIDVLTR RSSAQRQQIA
     KSFKAQFGSD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL
     ASRTKNQLQE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV TGFVDPGLAL
     QDAQDLYAAG EKICGTDEMK FITILCTRSA RHLMRVFEEY EKIANKSIED SIKSETHGSL
     EEAMLTIVKC TRNLHCYFAE RLHYAMKGAG TLDGTLIRNI VSRSEIDLNL IKGHYKKMYG
     KTLSSMIMED TSGDYKNALL SLVGSDP