ID   HMAT_HALSA              Reviewed;         489 AA.
AC   Q9HPR6; P71413;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Heme-based aerotactic transducer HemAT;
GN   Name=hemAT; Synonyms=htb, htr10; OrderedLocusNames=VNG_1505G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Flx15;
RX   PubMed=8643458; DOI=10.1073/pnas.93.10.4649;
RA   Zhang W., Brooun A., McCandless J., Banda P., Alam M.;
RT   "Signal transduction in the archaeon Halobacterium salinarium is processed
RT   through three subfamilies of 13 soluble and membrane-bound transducer
RT   proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:4649-4654(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [3]
RP   FUNCTION.
RX   PubMed=10676961; DOI=10.1038/35000570;
RA   Hou S., Larsen R.W., Boudko D., Riley C.W., Karatan E., Zimmer M.,
RA   Ordal G.W., Alam M.;
RT   "Myoglobin-like aerotaxis transducers in Archaea and Bacteria.";
RL   Nature 403:540-544(2000).
CC   -!- FUNCTION: Heme-containing signal transducer responsible for aerotaxis,
CC       the migratory response toward or away from oxygen.
CC       {ECO:0000269|PubMed:10676961}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; U75436; AAB17881.1; -; Genomic_DNA.
DR   EMBL; AE004437; AAG19801.1; -; Genomic_DNA.
DR   PIR; E84304; E84304.
DR   PIR; T44978; T44978.
DR   RefSeq; WP_010903098.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPR6; -.
DR   SMR; Q9HPR6; -.
DR   STRING; 64091.VNG_1505G; -.
DR   PaxDb; Q9HPR6; -.
DR   EnsemblBacteria; AAG19801; AAG19801; VNG_1505G.
DR   GeneID; 5953006; -.
DR   KEGG; hal:VNG_1505G; -.
DR   PATRIC; fig|64091.14.peg.1151; -.
DR   HOGENOM; CLU_000445_21_2_2; -.
DR   InParanoid; Q9HPR6; -.
DR   OMA; AMTITHI; -.
DR   OrthoDB; 41839at2157; -.
DR   PhylomeDB; Q9HPR6; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IDA:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009454; P:aerotaxis; IDA:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IDA:UniProtKB.
DR   CDD; cd01068; globin_sensor; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR044398; Globin-sensor_dom.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR039379; Protoglobin_sensor_dom.
DR   Pfam; PF00015; MCPsignal; 1.
DR   Pfam; PF11563; Protoglobin; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Reference proteome; Transducer.
FT   CHAIN           1..489
FT                   /note="Heme-based aerotactic transducer HemAT"
FT                   /id="PRO_0000110568"
FT   DOMAIN          218..454
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   CONFLICT        213..214
FT                   /note="SD -> TH (in Ref. 1; AAB17881)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        239
FT                   /note="A -> R (in Ref. 1; AAB17881)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        314
FT                   /note="R -> G (in Ref. 1; AAB17881)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        452
FT                   /note="D -> G (in Ref. 1; AAB17881)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   489 AA;  52852 MW;  8C0AEF179667791E CRC64;
     MSNDNDTLVT ADVRNGIDGH ALADRIGLDE AEIAWRLSFT GIDDDTMAAL AAEQPLFEAT
     ADALVTDFYD HLESYERTQD LFANSTKTVE QLKETQAEYL LGLGRGEYDT EYAAQRARIG
     KIHDVLGLGP DVYLGAYTRY YTGLLDALAD DVVADRGEEA AAAVDELVAR FLPMLKLLTF
     DQQIAMDTYI DSYAQRLHDE IDSRQELANA VASDVEAPLS SLEATSQDVA ERTDTMRAAT
     DDQVDRMADV SREISSVSAS VEEVASTADD VRRTSEDAEA LAQQGEAAAD DALATMTDID
     EATDGVTAGV EQLRERAADV ESVTGVIDDI AEQTNMLALN ASIEAARAGE AGEGFAVVAD
     EVKALAEESR EQSTRVEELV EQMQAETEET VDQLDEVNQR IGEGVERVEE AMETLQEITD
     AVEDAASGMQ EVSTATDEQA VSTEEVAEMV DDVDDRAGEI AAALDDIADA TDQQVRTVEE
     VRETVGKLS