ID   HMB1_STRPU              Reviewed;         308 AA.
AC   P13545;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Homeobox protein HB1;
DE   AltName: Full=SPHBOX1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Martinez P., Lee J., Davidson E.H.;
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-79.
RX   PubMed=2566559; DOI=10.1101/gad.3.3.370;
RA   Angerer L.M., Dolecki G.J., Gagnon M.L., Lum R., Yang W.Q., Humphreys T.,
RA   Angerer R.;
RT   "Progressively restricted expression of a homeo box gene within the aboral
RT   ectoderm of developing sea urchin embryos.";
RL   Genes Dev. 3:370-383(1989).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; D85419; BAA12813.1; -; mRNA.
DR   EMBL; X14509; CAA32661.1; -; Genomic_DNA.
DR   PIR; S04922; S04922.
DR   RefSeq; NP_999725.1; NM_214560.1.
DR   AlphaFoldDB; P13545; -.
DR   SMR; P13545; -.
DR   EnsemblMetazoa; NM_214560; NP_999725; GeneID_373356.
DR   GeneID; 373356; -.
DR   KEGG; spu:373356; -.
DR   CTD; 373356; -.
DR   HOGENOM; CLU_1379729_0_0_1; -.
DR   OMA; ITSWDAR; -.
DR   OrthoDB; 1014909at2759; -.
DR   PhylomeDB; P13545; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..308
FT                   /note="Homeobox protein HB1"
FT                   /id="PRO_0000049010"
FT   DNA_BIND        190..249
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          247..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           173..178
FT                   /note="Antp-type hexapeptide"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        262..280
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  33295 MW;  7F5C52DA602753C1 CRC64;
     MSSSSYFVNP AFFPTYPHAG EQFYATPSGS YELSSCAFSK NPKTSSYSSS SSPSLVATSK
     PPCTQQLGAA TFYGGGTLSN FSTTAGYGDH STTSAGYGSM SQPISPTSAW DSRMAATYNS
     ASWGSTAAEL GDGSYRGRVS ALTAGTGCLV SAAAEPNNNH CSQVMSPCKS TSGYPWMPVS
     GPNVGLEVGR KRCRQTYTRY QTLELEKEFH FNRYLTRRRR IELSHLLGLT ERQIKIWFQN
     RRMKYKKESK NKEEGGSGEG EGENESESTG TENAQPQSAV HGVTILEKPS SLVLHVDDTV
     GLNAVRHT