ID   HMB1_TRIGR              Reviewed;         307 AA.
AC   P09080;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 3.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Homeobox protein HB1;
DE   AltName: Full=TGHBOX1;
DE   Flags: Fragment;
OS   Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Tripneustes.
OX   NCBI_TaxID=7673;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2566559; DOI=10.1101/gad.3.3.370;
RA   Angerer L.M., Dolecki G.J., Gagnon M.L., Lum R., Yang W.Q., Humphreys T.,
RA   Angerer R.;
RT   "Progressively restricted expression of a homeo box gene within the aboral
RT   ectoderm of developing sea urchin embryos.";
RL   Genes Dev. 3:370-383(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 181-307.
RA   Dolecki G.J.;
RL   Submitted (OCT-1988) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-256.
RX   PubMed=3013625; DOI=10.1002/j.1460-2075.1986.tb04305.x;
RA   Dolecki G.J., Wannakrairoj S., Lum R., Wang G., Riley H.D., Carlos R.,
RA   Wang A., Humphreys T.;
RT   "Stage-specific expression of a homeo box-containing gene in the non-
RT   segmented sea urchin embryo.";
RL   EMBO J. 5:925-930(1986).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X14508; CAA32660.1; -; mRNA.
DR   EMBL; X13148; CAA31546.1; -; Genomic_DNA.
DR   PIR; S04923; S04923.
DR   AlphaFoldDB; P09080; -.
DR   SMR; P09080; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..307
FT                   /note="Homeobox protein HB1"
FT                   /id="PRO_0000049011"
FT   DNA_BIND        189..248
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          42..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           172..177
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        261..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        201
FT                   /note="T -> R (in Ref. 3)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   307 AA;  33291 MW;  4AB76DD556783F14 CRC64;
     NSGVFVNPPF FPTYPHAGEQ FYVTPPGSYE LSSCAFSSKN PKTSSYSSSS SPPSLTATSK
     PSCTQQLGAA TFYGGGTLSN FSTAGYGDHS TTSAGYGSMS QPISPTSAWD SRMAATYNTT
     SWGSTAAELG DGSYRGRVNA LAAGTGCLVS AAAEPNNNHC SQVMSPCKST SGYPWMPVAG
     PNVGLEVGRK RCRQTYTRYQ TLELEKEFHF NRYLTRRRRI ELSHLLGLTE RQIKIWFQNR
     RMKYKKESKN KEEGVSGEGD GENETESTGT ENAQTQNAVH GVTILEKPSS LVLHVDDTIA
     LNTVRHS