ID   HMB4_TRIGR              Reviewed;         107 AA.
AC   P10179;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Homeobox protein HB4;
DE   Flags: Fragment;
OS   Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Tripneustes.
OX   NCBI_TaxID=7673;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Sperm;
RX   PubMed=2905443; DOI=10.1093/nar/16.24.11543;
RA   Dolecki G.J., Wang G., Humphreys T.;
RT   "Stage- and tissue-specific expression of two homeo box genes in sea urchin
RT   embryos and adults.";
RL   Nucleic Acids Res. 16:11543-11558(1988).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; X13147; CAA31545.1; -; Genomic_DNA.
DR   PIR; S05259; S05259.
DR   AlphaFoldDB; P10179; -.
DR   SMR; P10179; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..107
FT                   /note="Homeobox protein HB4"
FT                   /id="PRO_0000049013"
FT   DNA_BIND        42..101
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
SQ   SEQUENCE   107 AA;  13173 MW;  44A4DF0FBD8A08AE CRC64;
     INIFMKKNCK CISFFIFFSI FFCRGREAEE RGHANWLSAT SGRKKRCPYT KFQTLELEKE
     FLFNMYLTRD RRLEIARLLS LTERQVKIWF QNRRMKMKKQ NRAQNYP