HMBX1_CAEEL
ID HMBX1_CAEEL Reviewed; 424 AA.
AC Q9TYT0;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Homeobox-containing protein 1 {ECO:0000250|UniProtKB:Q6NT76};
GN Name=hmbx-1 {ECO:0000303|PubMed:20713521, ECO:0000312|WormBase:F54A5.1};
GN ORFNames=F54A5.1 {ECO:0000312|WormBase:F54A5.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP DOMAIN, AND MUTAGENESIS OF HIS-404.
RX PubMed=20713521; DOI=10.1101/gad.1932610;
RA Lesch B.J., Bargmann C.I.;
RT "The homeodomain protein hmbx-1 maintains asymmetric gene expression in
RT adult C. elegans olfactory neurons.";
RL Genes Dev. 24:1802-1815(2010).
CC -!- FUNCTION: Transcriptional repressor which maintains cell fate asymmetry
CC of AWC neurons in adults by repressing the expression of multiple AWC
CC (OFF) genes, including srsx-3 in the AWC (ON) neuron.
CC {ECO:0000269|PubMed:20713521}.
CC -!- INTERACTION:
CC Q9TYT0; Q18097: CELE_C18E9.8; NbExp=4; IntAct=EBI-324959, EBI-2413660;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000305|PubMed:20713521}.
CC -!- TISSUE SPECIFICITY: Expressed in both AWC neurons (PubMed:20713521).
CC Also expressed in the FLP mechanosensory neurons (PubMed:20713521).
CC {ECO:0000269|PubMed:20713521}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown has little effect on
CC srsx-3 expression in the AWC neuron. {ECO:0000269|PubMed:20713521}.
CC -!- SIMILARITY: Belongs to the HMBOX1 homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284601; CCD68059.1; -; Genomic_DNA.
DR PIR; C87723; C87723.
DR PIR; T32913; T32913.
DR PIR; T33839; T33839.
DR RefSeq; NP_490803.1; NM_058402.5.
DR AlphaFoldDB; Q9TYT0; -.
DR SMR; Q9TYT0; -.
DR DIP; DIP-27471N; -.
DR IntAct; Q9TYT0; 4.
DR STRING; 6239.F54A5.1; -.
DR PaxDb; Q9TYT0; -.
DR EnsemblMetazoa; F54A5.1.1; F54A5.1.1; WBGene00018786.
DR GeneID; 171679; -.
DR UCSC; F54A5.1; c. elegans.
DR CTD; 171679; -.
DR WormBase; F54A5.1; CE20859; WBGene00018786; hmbx-1.
DR eggNOG; ENOG502QQSR; Eukaryota.
DR GeneTree; ENSGT00940000154928; -.
DR HOGENOM; CLU_650902_0_0_1; -.
DR InParanoid; Q9TYT0; -.
DR OMA; FEHPICS; -.
DR OrthoDB; 1342373at2759; -.
DR PhylomeDB; Q9TYT0; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00018786; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR040363; HMBOX1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14618; PTHR14618; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..424
FT /note="Homeobox-containing protein 1"
FT /id="PRO_0000451153"
FT DOMAIN 1..30
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 103..199
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 215..291
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 291..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 404
FT /note="H->Y: In ky777; expression of G protein-coupled
FT receptor (GPCR), srsx-3, in olfactory neuron AWC (OFF) is
FT lost after larval stage L1, but expression of GPCR str-2 in
FT AWC(ON) is retained. Phenotype effects are more severe in
FT older adults than in young adults."
FT /evidence="ECO:0000269|PubMed:20713521"
SQ SEQUENCE 424 AA; 47026 MW; A07895C5B3CE380A CRC64;
MLFTIEQLEL IKKLQHTGMS SDQLLKAFGE LEVPEQLQNN NTIAAALYSP LLVQHLTTPK
SETPVKLTVQ TVPTPVKSEP QSSNCSSPFE HPICSNAPRP IRSQRTPMKE ITTLDDPNEL
EEFMKQGEEA CILDMKTFIT QYSLRQTTVA MMTGVSQPYI SKLLNGNHRE LSLRCRKNIY
CWYLNCRRHP NKLAAFLADP TTRLETNGDG ELIPQRRERY VFRPILIRML ESFFTQTPFP
DLPRRVEIAN ACNHVLKMDK KGVGLMPKEV VSPQVVSNWF ANKRKELRRR SAEASAASTS
SASSSASSTA NHDSVSVSSM SPRDEETSSR NTTPETAISP SPAVSTFEVS RPSAIISATS
STTSPISIPA TIIPSVSPSA LELFAMAQQL GVQLPVPFPT LPTHFFPFQM APFYGNPASI
LKSE
