ID   HMC3_DESVH              Reviewed;         388 AA.
AC   P33390;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Protein DVU_0534;
DE   AltName: Full=HMC operon ORF 3;
GN   OrderedLocusNames=DVU_0534;
OS   Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS   B-1760 / Hildenborough).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8335628; DOI=10.1128/jb.175.15.4699-4711.1993;
RA   Rossi M., Pollock W.B.R., Reij M.W., Keon R.G., Fu R., Voordouw G.;
RT   "The hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough
RT   encodes a potential transmembrane redox protein complex.";
RL   J. Bacteriol. 175:4699-4711(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX   PubMed=15077118; DOI=10.1038/nbt959;
RA   Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA   Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA   Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA   Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA   Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA   Wall J.D., Voordouw G., Fraser C.M.;
RT   "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT   Desulfovibrio vulgaris Hildenborough.";
RL   Nat. Biotechnol. 22:554-559(2004).
CC   -!- FUNCTION: HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4,
CC       ORF5 and ORF6 in the HMC operon form a transmembrane protein complex
CC       that allows electron flow from the periplasmic hydrogenase to the
CC       cytoplasmic enzymes that catalyze reduction of sulfates.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the NrfD family. {ECO:0000305}.
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DR   EMBL; L16784; AAA71996.1; -; Unassigned_DNA.
DR   EMBL; AE017285; AAS95016.1; -; Genomic_DNA.
DR   PIR; C40605; C40605.
DR   RefSeq; WP_010937840.1; NZ_CABHLV010000001.1.
DR   RefSeq; YP_009757.1; NC_002937.3.
DR   AlphaFoldDB; P33390; -.
DR   SMR; P33390; -.
DR   STRING; 882.DVU_0534; -.
DR   PaxDb; P33390; -.
DR   EnsemblBacteria; AAS95016; AAS95016; DVU_0534.
DR   KEGG; dvu:DVU_0534; -.
DR   PATRIC; fig|882.5.peg.510; -.
DR   eggNOG; COG5557; Bacteria.
DR   HOGENOM; CLU_049007_0_0_7; -.
DR   OMA; SNDYPWG; -.
DR   PhylomeDB; P33390; -.
DR   Proteomes; UP000002194; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005614; NrfD_fam.
DR   Pfam; PF03916; NrfD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..388
FT                   /note="Protein DVU_0534"
FT                   /id="PRO_0000159325"
FT   TRANSMEM        10..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  43163 MW;  87203E4F6BB19FD2 CRC64;
     MQHANTNKSL MTPGNIITGI ILVMGLVLTV LRFTKGIGAV SNLDDNNPWG IWIGFDLLCG
     VALAAGGYVT SASCYLFGMK RYHSAVRPAI TTAFLGYFFV VVALNYDLGH PLRLPYPLVY
     SQGTTSLLFE VGLCVATYLT VLFVEWSPAA LEWLGLRKIR NVVVKLTLVL TIFGVVLSTL
     HQSSLGALFL IAPSKLHPLW YSSFLPVFFF ISSMVAGLSM VIFEGSLAHK GMHHMMDETH
     LKEADGVVFG FGKAASFVLA GYFMIKVIDV TMDNDWHYLA TGYGAWWLVE MLGFVALPSF
     LYALGVREKR IGVIRFASVL GVLGIVMNRF NVCLVAFNWQ LPADQRYFPH WMEIGISVFI
     VTSIITVYRF IASRMPVLYE HPDYKDAH