HMCN2_HUMAN
ID HMCN2_HUMAN Reviewed; 5059 AA.
AC Q8NDA2; A0A096LP30; Q8N225; Q8TCI8;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Hemicentin-2 {ECO:0000305};
DE Flags: Precursor;
GN Name=HMCN2 {ECO:0000312|HGNC:HGNC:21293};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3787-5059 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4756-5059 (ISOFORM 1).
RC TISSUE=Small intestine, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3096-5059 (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:A2AJ76}. Cleavage furrow
CC {ECO:0000250|UniProtKB:A2AJ76}. Note=The antibody used to determine
CC subcellular location does not distinguish between HMCN1 and HMCN2.
CC {ECO:0000250|UniProtKB:A2AJ76}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NDA2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDA2-2; Sequence=VSP_039367, VSP_039368;
CC Name=3;
CC IsoId=Q8NDA2-4; Sequence=VSP_058197, VSP_058198;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85069.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04201.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD38854.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=EAW87931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; ABBA01012042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABBA01043973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL360004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AUXG01000072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FP565345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87931.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK074396; BAB85069.1; ALT_INIT; mRNA.
DR EMBL; AK093583; BAC04201.1; ALT_INIT; mRNA.
DR EMBL; AL834139; CAD38854.1; ALT_SEQ; mRNA.
DR STRING; 9606.ENSP00000485357; -.
DR GlyGen; Q8NDA2; 40 sites.
DR iPTMnet; Q8NDA2; -.
DR PhosphoSitePlus; Q8NDA2; -.
DR SwissPalm; Q8NDA2; -.
DR BioMuta; HMCN2; -.
DR DMDM; 298351848; -.
DR EPD; Q8NDA2; -.
DR jPOST; Q8NDA2; -.
DR MassIVE; Q8NDA2; -.
DR PaxDb; Q8NDA2; -.
DR PeptideAtlas; Q8NDA2; -.
DR PRIDE; Q8NDA2; -.
DR ProteomicsDB; 72996; -. [Q8NDA2-1]
DR ProteomicsDB; 72997; -. [Q8NDA2-2]
DR Antibodypedia; 65468; 13 antibodies from 6 providers.
DR Ensembl; ENST00000624552.4; ENSP00000485357.2; ENSG00000148357.18.
DR UCSC; uc064wnb.1; human.
DR GeneCards; HMCN2; -.
DR HGNC; HGNC:21293; HMCN2.
DR HPA; ENSG00000148357; Tissue enhanced (endometrium, intestine).
DR neXtProt; NX_Q8NDA2; -.
DR PharmGKB; PA142671680; -.
DR VEuPathDB; HostDB:ENSG00000148357; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; Q8NDA2; -.
DR PathwayCommons; Q8NDA2; -.
DR ChiTaRS; HMCN2; human.
DR Pharos; Q8NDA2; Tdark.
DR PRO; PR:Q8NDA2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NDA2; protein.
DR Bgee; ENSG00000148357; Expressed in muscle layer of sigmoid colon and 129 other tissues.
DR ExpressionAtlas; Q8NDA2; baseline and differential.
DR GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 2.40.155.10; -; 1.
DR Gene3D; 2.60.40.10; -; 43.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR032984; Hemicentin-2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23278:SF29; PTHR23278:SF29; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF07679; I-set; 33.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00409; IG; 43.
DR SMART; SM00408; IGc2; 43.
DR SMART; SM00406; IGv; 14.
DR SUPFAM; SSF48726; SSF48726; 43.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF54511; SSF54511; 1.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS50835; IG_LIKE; 42.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Disulfide bond; EGF-like domain;
KW Extracellular matrix; Glycoprotein; Immunoglobulin domain; Methylation;
KW Reference proteome; Repeat; Secreted; Sensory transduction; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..5059
FT /note="Hemicentin-2"
FT /id="PRO_0000395108"
FT DOMAIN 38..205
FT /note="VWFA"
FT DOMAIN 517..602
FT /note="Ig-like C2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 607..690
FT /note="Ig-like C2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 697..780
FT /note="Ig-like C2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 785..879
FT /note="Ig-like C2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 884..970
FT /note="Ig-like C2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 975..1061
FT /note="Ig-like C2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1066..1159
FT /note="Ig-like C2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1164..1244
FT /note="Ig-like C2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1265..1338
FT /note="Ig-like C2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1343..1429
FT /note="Ig-like C2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1436..1525
FT /note="Ig-like C2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1530..1618
FT /note="Ig-like C2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1623..1714
FT /note="Ig-like C2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1717..1805
FT /note="Ig-like C2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1810..1887
FT /note="Ig-like C2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1894..1982
FT /note="Ig-like C2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1985..2074
FT /note="Ig-like C2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2079..2165
FT /note="Ig-like C2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2170..2261
FT /note="Ig-like C2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2264..2353
FT /note="Ig-like C2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2358..2447
FT /note="Ig-like C2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2452..2540
FT /note="Ig-like C2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2545..2636
FT /note="Ig-like C2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2641..2732
FT /note="Ig-like C2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2739..2833
FT /note="Ig-like C2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2849..2938
FT /note="Ig-like C2-type 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 2945..3032
FT /note="Ig-like C2-type 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3037..3127
FT /note="Ig-like C2-type 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3131..3219
FT /note="Ig-like C2-type 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3224..3314
FT /note="Ig-like C2-type 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3319..3406
FT /note="Ig-like C2-type 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3412..3497
FT /note="Ig-like C2-type 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3502..3588
FT /note="Ig-like C2-type 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3593..3681
FT /note="Ig-like C2-type 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3686..3772
FT /note="Ig-like C2-type 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3777..3848
FT /note="Ig-like C2-type 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3851..3937
FT /note="Ig-like C2-type 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3942..4027
FT /note="Ig-like C2-type 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 4031..4118
FT /note="Ig-like C2-type 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 4123..4204
FT /note="Ig-like C2-type 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 4212..4295
FT /note="Ig-like C2-type 41"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 4303..4388
FT /note="Ig-like C2-type 42"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 4392..4614
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00348"
FT DOMAIN 4628..4668
FT /note="EGF-like 1; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4669..4712
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4713..4751
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4756..4796
FT /note="EGF-like 4; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4863..4902
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 1270..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 911
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:A2AJ76"
FT MOD_RES 916
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:A2AJ76"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 477
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 524
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 673
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1023
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1071
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1536
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1562
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1670
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1819
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1908
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2008
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2087
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2093
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2443
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2580
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2662
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2866
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 2960
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3404
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3534
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3549
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3696
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 3700
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 4062
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 4264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 4415
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 4561
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 4804
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 4994
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 537..586
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 628..676
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 718..764
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 806..861
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 905..954
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 996..1045
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1094..1143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1185..1228
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1272..1322
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1366..1415
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1459..1509
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1553..1602
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1647..1696
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1740..1789
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1832..1873
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1915..1964
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2007..2058
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2100..2149
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2192..2243
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2288..2337
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2382..2431
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2475..2524
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2571..2620
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2669..2718
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2780..2829
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2875..2924
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2967..3016
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3062..3111
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3154..3203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3247..3298
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3343..3392
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3436..3481
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3525..3572
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3616..3665
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3707..3756
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3779..3830
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3872..3921
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3963..4011
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4053..4102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4144..4191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4234..4282
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4324..4372
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4632..4643
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4639..4652
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4654..4667
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4673..4686
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4680..4695
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4699..4711
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4717..4730
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4724..4739
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4760..4771
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4767..4780
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4782..4795
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4867..4877
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4873..4886
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 4888..4901
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 3409..3446
FT /note="VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV -> CPLSWSRWSS
FT RMTWWWFVAPWWNSRARPGAFPCLSCRG (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_058197"
FT VAR_SEQ 3447..5059
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_058198"
FT VAR_SEQ 4165..4192
FT /note="EGVSEQDGGSTLQRAAVSREDSGTYVCW -> GLGLLGMGGTESQDTGRLRR
FT EGRWGDPT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039367"
FT VAR_SEQ 4193..5059
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039368"
FT CONFLICT 3289
FT /note="R -> W (in Ref. 4; CAD38854)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 5059 AA; 541978 MW; 5933D04A2F9AF3D7 CRC64;
MPGAPLLRLL TAVSAAVAVA VAGAPGTVMP PTTGDATLAF VFDVTGSMWD ELMQVIDGAS
RILERSLSRR SQAIANYALV PFHDPDIGPV TLTADPTVFQ RELRELYVQG GGDCPEMSVG
AIKAAVEVAN PGSFIYVFSD ARAKDYHKKE ELLRLLQLKQ SQVVFVLTGD CGDRTHPGYL
AYEEIAATSS GQVFHLDKQQ VTEVLKWVES AIQASKVHLL STDHEEEGEH TWRLPFDPSL
KEVTISLSGP GPEIEVQDPL GRILQEDEGL NVLLNIPDSA KVVAFKPEHP GLWSIKVYSS
GRHSVRITGV SNIDFRAGFS TQPLLDLNHT LEWPLQGVPI SLVINSTGLK APGRLDSVEL
AQSSGKPLLT LPTKPLSNGS THQLWGGPPF HTPKERFYLK VKGKDHEGNP LLRVSGVSYS
GVAPGAPLVS MAPRIHGYLH QPLLVSCSVH SALPFRLQLR RGEARLGEER HFQESGNSSW
EILRASKAEE GTYECTAVSR AGTGRAKAQI VVTDPPPQLV PAPNVTVSPG ETAVLSCRVL
GEAPYNLTWV RDWRVLPAST GRVAQLADLS LEISGIIPTD GGRYQCVASN ANGVTRASVW
LLVREAPQVS IHTSSQHFSQ GVEVKVSCSA SGYPTPHISW SRESQALQED SRIHVDAQGT
LIIQGVAPED AGNYSCQATN EVGTDQETVT LYYTDPPSVS AVNAVVLVAV GEEAVLVCEA
SGVPPPRVIW YRGGLEMILA PEGSSSGKLR IPAAQERDAG TYTCRAVNEL GDASAEIQLA
VGHAPQLTEL PRDVTVELGR SALLACRATG RPPPTVTWRR GDGQPLGLRL GAGRGSRSRQ
PDSGVLFFES VAPEDQAPYV CEARNVFGKV QAEARLIVTG HAPPQIASSA PTVRVLEGQP
VSLPCIVLAG RPLPERHWLK DGRPLPPGSR HSIRADGSLH LDRALQEHAG RYSCVATNTA
GSQHRDVELV VQVPPRIHPT ATHHITNEGV AASLPCVASG VPAPTITWTK ETNALTSRGP
HYNVSKEGTL LIAQPSAQDA GAYVCTATNT VGFSSQEMRL SVNTKPRIHM NGSRNADVPL
QVTAKAGEEV TLDCEAKGSP PPLVTWTKDS RPVPPITNRY GLLPSGSLRL AQVQVGDSGH
YECTASNPAG SASHRYVLGV QVPPQVQPGP RVLKVLVGEA LDLNCVAEGN PEPQLSWSKD
GVVLQGRGPQ GSVHFAAIRT SDAGRYRCEA SNSAGVDAWE VELRVLEPPH WGADETSGLL
ERVAGENASL PCPARGTPKP QVTWRKGPSS EPLHGQPGVA VLEEGSLFLA SVSPADSGDY
ECQATNEVGS TSRRAKLVVY VPPSIREDGR KANVSGMAGQ SLTLECDANG FPVPEIVWLK
DAQLIPKVGG HRLLDEGQSL HFPRIQEGDS GLYSCRAENQ AGTAQRDFHL LVLTPPSVLG
AGAAQEVLGL AGADVELQCW TSGVPTPQVE WTKDRQPVLP GGPHLQVQED GQVLRITGSH
VGDEGRYQCV AFSPAGQQAR DFQLRVHAPP TIWGSNETGE VAVMEDHLVQ LLCEARGVPT
PNITWFKDGA LLPTSTKVVY TRGGRQLQLG RAQSSDAGVY TCKASNAVGA AEKATRLDVY
VPPTIEGAGG RPYVVKAVAG RPVALECVAR GHPSPTLSWH HEGLPVAESN ESRLETDGSV
LRLESPGEAS SGLYSCVASS PAGEAVLQYS VEVQVPPQLL VAEGLGQVTT IVGQPLELPC
QASGSPVPTI QWLQNGRPAE ELAGVQVASQ GTTLHIDHVE LDHSGLFACQ ATNEAGTAGA
EVEVSVHEFP SVSIIGGENI TAPFLQPVTL QCIGDGVPTP SLRWWKDGVA LAAFGGNLQI
EKVDLRDEGI YTCAATNLAG ESKREVALKV LVPPNIEPGP VNKAVLENAS VTLECLASGV
PPPDVSWFKG HQPVSSWMGV TVSVDGRVLR IEQAQLSDAG SYRCVASNVA GSTELRYGLR
VNVPPRITLP PSLPGPVLVN TPVRLTCNAT GAPSPTLMWL KDGNPVSPAG TPGLQVFPGG
RVLTLASARA SDSGRYSCVA VSAVGEDRQD VVLQVHMPPS ILGEELNVSV VANESVALEC
QSHAMPPPVL SWWKDGRPLE PRPGVHLSAD KALLQVDRAD VWDAGHYTCE ALNQAGHSEK
HYNLNVWVAP VFPLRESHTL TVREGHPTRL SCECRGVPFP KISWRKDGQP LPGEGAGLQH
VSAVGRLLYL GQAQLAQEGT YTCECSNVVG NSSQDLQLEV HVPPQIAGPR EPPTQVSVVQ
DGVATLECNA TGKPPPTVTW ERDGQPVGAE LGLQLQNQGQ SLHVERAQAA HTGRYSCVAE
NLAGRAERKF ELSVLVPPEL IGDLDPLTNI TAALHSPLTL LCEAMGIPPP AIRWFRGEEP
VSPGEDTYLL AGGWMLKMTQ TQEQDSGLYS CLASNEAGEA RRNFSVEVLV PPSIENEDLE
EVIKVLDGQT AHLMCNVTGH PQPKLTWFKD GRPLARGDAH HISPDGVLLQ VLQANLSSAG
HYSCIAANAV GEKTKHFQLS VLLAPTILGG AEDSADEEVT VTVNNPISLI CEALAFPSPN
ITWMKDGAPF EASRNIQLLP GTHGLQILNA QKEDAGQYTC VVTNELGEAV KNYHVEVLIP
PSISKDDPLA EVGVKEVKTK VNSTLTLECE SWAVPPPTIR WYKDGQPVTP SSRLQVLGEG
RLLQIQPTQV SDSGRYLCVA TNVAGEDDQD FNVLIQVPPM FQKVGDFSAA FEILSREEEA
RGGVTEYREI VENNPAYLYC DTNAIPPPDL TWYREDQPLS AGDEVSVLQG GRVLQIPLVR
AENAGRYSCK ASNEVGEDWL HYELLVLTPP VILGDTEELV EEVTVNASST VSLQCPALGN
PVPTISWLQN GLPFSPSPRL QVLEDGQVLQ VSTAEVADAA SYMCVAENQA GSAEKLFTLR
VQVPPRIAGL DLEQVTAILN SSVSLPCDVH AHPNPEVTWY KDSQALSLGE EVFLLPGTHT
LQLGRARLSD SGMYTCEALN AAGRDQKLVQ LSVLVPPAFR QAPRGPQDAV LVRVGDKAVL
SCETDALPEP TVTWYKDGQP LVLAQRTQAL RGGQRLEIQE AQVSDKGLYS CKVSNVAGEA
VRTFTLTVQV PPTFENPKTE TVSQVAGSPL VLTCDVSGVP APTVTWLKDR MPVESSAVHG
VVSRGGRLQL SRLQPAQAGT YTCVAENTQA EARKDFVVAV LVAPRIRSSG VAREHHVLEG
QEVRLDCEAD GQPPPDVAWL KDGSPLGQDM GPHLRFYLDG GSLVLKGLRA SDAGAYTCVA
HNPAGEDARL HTVNVLVPPT IKQGADGSGT LVSRPGELVT MVCPVRGSPP IHVSWLKDGL
PLPLSQRTLL HGSGHTLRIS KVQLADAGIF TCVAASPAGV ADRNFTLQVQ VPPVLEPVEF
QNDVVVVRGS LVELPCEARG VPLPLVSWMK DGEPLLSQSL EQGPSLQLEA VGAGDSGTYS
CVAVSEAGEA RRHFQLTVME PPHIEDSGQP TELSLTPGAP MELLCDAQGT PQPNITWHKD
GQALTRLENN SRATRVLRVE NVQVRDAGLY TCLAESPAGA IEKSFRVRVQ APPNIVGPRG
PRFVVGLAPG QLVLECSVEA EPAPKITWHR DGIVLQEDAH TQFPERGRFL QLQALSTADS
GDYSCTARNA AGSTSVAFRV EIHTVPTIRS GPPAVNVSVN QTALLPCQAD GVPAPLVSWR
KDRVPLDPRS PRFEILPEGS LRIQPVLAQD AGHYLCLASN SAGSDRQGRD LRVLALLPCE
ASGSPKPLVV WWKDGQKLDF RLQQGAYRLL PSNALLLTAP GPQDSAQFEC VVSNEVGEAH
RLYQVTVHVP PTIADDQTDF TVTMMAPVVL TCHSTGIPAP TVSWSKAGAQ LGARGSGYRV
SPSGALEIGQ ALPIHAGRYT CSARNSAGVA HKHVFLTVQA SPVVKPLPSV VRAVAEEEVL
LPCEASGIPR PTITWQKEGL NVATGVSTQV LPGGQLRIAH ASPEDAGNYL CIAKNSAGSA
MGKTRLVVQV PPVIENGLPD LSTTEGSHAF LPCKARGSPE PNITWDKDGQ PVSGAEGKFT
IQPSGELLVK NLEGQDAGTY TCTAENAVGR ARRRVHLTIL VLPVFTTLPG DRSLRLGDRL
WLRCAARGSP TPRIGWTVND RPVTEGVSEQ DGGSTLQRAA VSREDSGTYV CWAENRVGRT
QAVSFVHVKE APVLQGEAFS YLVEPVGGSI QLDCVVRGDP VPDIHWIKDG LPLRGSHLRH
QLQNGSLTIR RTERDDAGRY QCLAENEMGV AKKVVILVLQ SAPVFQVEPQ DMTVRSGDDV
ALRCQATGEP TPTIEWLQAG QPLRASRRLR TLPDGSLWLE NVETGDAGTY DCVAHNLLGS
ATARAFLVVR GEPQGSWGSM TGVINGRKFG VATLNTSVMQ EAHSGVSSIH SSIRHVPANV
GPLMRVLVVT IAPIYWALAR ESGEALNGHS LTGGRFRQES HVEFATGELL TMTQVARGLD
PDGLLLLDVV VNGVVPESLA DADLQVQDFE EHYVQTGPGQ LFVGSTQRFF QGGLPSFLRC
NHSIQYNAAR GPQPQLVQHL RASAISSAFD PEAEALRFQL ATALQAEENE VGCPEGFELD
SQGAFCVDRD ECSGGPSPCS HACLNAPGRF SCTCPTGFAL AWDDRNCRDV DECAWDAHLC
REGQRCVNLL GSYRCLPDCG PGFRVADGAG CEDVDECLEG LDDCHYNQLC ENTPGGHRCS
CPRGYRMQGP SLPCLDVNEC LQLPKACAYQ CHNLQGSYRC LCPPGQTLLR DGKACTSLER
NGQNVTTVSH RGPLLPWLRP WASIPGTSYH AWVSLRPGPM ALSSVGRAWC PPGFIRQNGV
CTDLDECRVR NLCQHACRNT EGSYQCLCPA GYRLLPSGKN CQDINECEEE SIECGPGQMC
FNTRGSYQCV DTPCPATYRQ GPSPGTCFRR CSQDCGTGGP STLQYRLLPL PLGVRAHHDV
ARLTAFSEVG VPANRTELSM LEPDPRSPFA LRPLRAGLGA VYTRRALTRA GLYRLTVRAA
APRHQSVFVL LIAVSPYPY
