ANXB9_DROME
ID ANXB9_DROME Reviewed; 324 AA.
AC P22464; A4V371; B5RJE6; Q8IGJ8; Q969D3; Q9NG55; Q9VDF3;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Annexin B9;
DE AltName: Full=Annexin IX;
DE AltName: Full=Annexin-9;
GN Name=AnxB9; Synonyms=AnnIX; ORFNames=CG5730;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RA Stoltzfus J.R., Grotewiel M.S.;
RT "Novel isoform of annexin IX from Drosophila melanogaster.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C).
RC STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 29-324 (ISOFORM A), AND DEVELOPMENTAL STAGE.
RC TISSUE=Head;
RX PubMed=2141610; DOI=10.1016/s0021-9258(19)38604-1;
RA Johnston P.A., Perin M.S., Reynolds G.A., Wasserman S.A., Suedhof T.C.;
RT "Two novel annexins from Drosophila melanogaster. Cloning,
RT characterization, and differential expression in development.";
RL J. Biol. Chem. 265:11382-11388(1990).
CC -!- INTERACTION:
CC P22464-3; Q9VL93: Dmel\CG13117; NbExp=4; IntAct=EBI-26781545, EBI-179106;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a; Synonyms=A;
CC IsoId=P22464-1; Sequence=Displayed;
CC Name=b; Synonyms=B, D;
CC IsoId=P22464-2; Sequence=VSP_009664;
CC Name=c; Synonyms=C;
CC IsoId=P22464-3; Sequence=VSP_009665;
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development with highest
CC expression seen in adults. {ECO:0000269|PubMed:2141610}.
CC -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC and phospholipid. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU01245, ECO:0000305}.
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DR EMBL; AF261718; AAF69016.1; -; mRNA.
DR EMBL; AY007377; AAG12161.1; -; mRNA.
DR EMBL; AE014297; AAF55841.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13848.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65188.1; -; Genomic_DNA.
DR EMBL; AE014297; AAS65189.1; -; Genomic_DNA.
DR EMBL; AY118504; AAM49873.1; -; mRNA.
DR EMBL; BT001749; AAN71504.1; -; mRNA.
DR EMBL; BT044420; ACH92485.1; -; mRNA.
DR EMBL; M34068; AAA28370.1; -; mRNA.
DR PIR; A42234; LUFF9.
DR RefSeq; NP_001262796.1; NM_001275867.1. [P22464-3]
DR RefSeq; NP_001262797.1; NM_001275868.1. [P22464-3]
DR RefSeq; NP_476603.1; NM_057255.3. [P22464-2]
DR RefSeq; NP_476604.1; NM_057256.4. [P22464-1]
DR RefSeq; NP_996252.1; NM_206530.2. [P22464-2]
DR RefSeq; NP_996253.1; NM_206531.2. [P22464-3]
DR AlphaFoldDB; P22464; -.
DR SMR; P22464; -.
DR BioGRID; 67463; 11.
DR DIP; DIP-20322N; -.
DR IntAct; P22464; 7.
DR STRING; 7227.FBpp0088506; -.
DR PaxDb; P22464; -.
DR PRIDE; P22464; -.
DR DNASU; 42492; -.
DR EnsemblMetazoa; FBtr0089517; FBpp0088505; FBgn0000083. [P22464-1]
DR EnsemblMetazoa; FBtr0089518; FBpp0088506; FBgn0000083. [P22464-2]
DR EnsemblMetazoa; FBtr0089519; FBpp0088986; FBgn0000083. [P22464-3]
DR EnsemblMetazoa; FBtr0089520; FBpp0088985; FBgn0000083. [P22464-2]
DR EnsemblMetazoa; FBtr0336797; FBpp0307769; FBgn0000083. [P22464-3]
DR EnsemblMetazoa; FBtr0336798; FBpp0307770; FBgn0000083. [P22464-3]
DR GeneID; 42492; -.
DR KEGG; dme:Dmel_CG5730; -.
DR UCSC; CG5730-RD; d. melanogaster.
DR CTD; 42492; -.
DR FlyBase; FBgn0000083; AnxB9.
DR VEuPathDB; VectorBase:FBgn0000083; -.
DR eggNOG; KOG0819; Eukaryota.
DR GeneTree; ENSGT00940000172288; -.
DR HOGENOM; CLU_025300_0_2_1; -.
DR InParanoid; P22464; -.
DR OMA; QQYYPFK; -.
DR PhylomeDB; P22464; -.
DR BioGRID-ORCS; 42492; 0 hits in 3 CRISPR screens.
DR ChiTaRS; AnxB9; fly.
DR GenomeRNAi; 42492; -.
DR PRO; PR:P22464; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000083; Expressed in oviduct (Drosophila) and 25 other tissues.
DR ExpressionAtlas; P22464; baseline and differential.
DR Genevisible; P22464; DM.
DR GO; GO:0005938; C:cell cortex; IDA:FlyBase.
DR GO; GO:0012505; C:endomembrane system; IDA:FlyBase.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; ISS:FlyBase.
DR GO; GO:0030507; F:spectrin binding; IPI:FlyBase.
DR GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IMP:FlyBase.
DR GO; GO:0030011; P:maintenance of cell polarity; IMP:FlyBase.
DR GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase.
DR Gene3D; 1.10.220.10; -; 4.
DR InterPro; IPR001464; Annexin.
DR InterPro; IPR018502; Annexin_repeat.
DR InterPro; IPR018252; Annexin_repeat_CS.
DR InterPro; IPR037104; Annexin_sf.
DR Pfam; PF00191; Annexin; 4.
DR PRINTS; PR00196; ANNEXIN.
DR SMART; SM00335; ANX; 4.
DR SUPFAM; SSF47874; SSF47874; 1.
DR PROSITE; PS00223; ANNEXIN_1; 3.
DR PROSITE; PS51897; ANNEXIN_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..324
FT /note="Annexin B9"
FT /id="PRO_0000067516"
FT REPEAT 21..92
FT /note="Annexin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 93..164
FT /note="Annexin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 176..248
FT /note="Annexin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT REPEAT 252..323
FT /note="Annexin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT VAR_SEQ 308..324
FT /note="EDAETDIGYVLVTLTAW -> DDLSGDYSYVLQCLASY (in isoform
FT b)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.1"
FT /id="VSP_009664"
FT VAR_SEQ 308..324
FT /note="EDAETDIGYVLVTLTAW -> GDTSGDYKRALLAIVGF (in isoform
FT c)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.5"
FT /id="VSP_009665"
FT CONFLICT 13
FT /note="P -> H (in Ref. 4; AAN71504)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="M -> L (in Ref. 1; AAG12161 and 6; AAA28370)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 36058 MW; 6DBF1021A7CC0DCA CRC64;
MSSAEYYPFK CTPTVYPADP FDPVEDAAIL RKAMKGFGTD EKAIIEILAR RGIVQRLEIA
EAFKTSYGKD LISDLKSELG GKFEDVILAL MTPLPQFYAQ ELHDAISGLG TDEEAIIEIL
CTLSNYGIKT IAQFYEQSFG KSLESDLKGD TSGHFKRLCV SLVQGNRDEN QGVDEAAAIA
DAQALHDAGE GQWGTDESTF NSILITRSYQ QLRQIFLEYE NLSGNDIEKA IKREFSGSVE
KGFLAIVKCC KSKIDYFSER LHDSMAGMGT KDKTLIRIIV SRSEIDLGDI KEAFQNKYGK
SLESWIKEDA ETDIGYVLVT LTAW
