HMD1_CHICK
ID HMD1_CHICK Reviewed; 248 AA.
AC P46692;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Homeobox protein CHOX-CAD;
GN Name=CHOX-CAD1; Synonyms=CHOX-CAD;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Oviduct;
RX PubMed=1685114; DOI=10.1242/dev.112.1.207;
RA Frumkin A., Rangini Z., Ben-Yehuda A., Gruenbaum Y., Fainsod A.;
RT "A chicken caudal homologue, CHox-cad, is expressed in the epiblast with
RT posterior localization and in the early endodermal lineage.";
RL Development 112:207-219(1991).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=7680627; DOI=10.1006/dbio.1993.1066;
RA Doll U., Niessing J.;
RT "Continued expression of the chicken caudal homologue in endodermally
RT derived organs.";
RL Dev. Biol. 156:155-163(1993).
CC -!- FUNCTION: May play an important role during the early steps of
CC organogenesis. {ECO:0000269|PubMed:7680627}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
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DR EMBL; X57760; CAA40915.1; -; Genomic_DNA.
DR EMBL; X57761; CAA40915.1; JOINED; Genomic_DNA.
DR PIR; S16417; S16417.
DR AlphaFoldDB; P46692; -.
DR SMR; P46692; -.
DR VEuPathDB; HostDB:geneid_395397; -.
DR InParanoid; P46692; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR006820; Caudal_activation_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF04731; Caudal_act; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..248
FT /note="Homeobox protein CHOX-CAD"
FT /id="PRO_0000049018"
FT DNA_BIND 137..196
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 192..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 248 AA; 27401 MW; CEF28690E5ED8B79 CRC64;
MYPSPVRHPG LNLNPQNYVP GPPQYSDFAS YHHVPGINND PHHGQPAAAW GSPYTPAKED
WHSYGTAAAS AATNPGQFGF SPPDFNPMQP HAGSGLLPPA ISSSVPQLSP NAQRRTPYEW
MRRSIPSTSS SGKTRTKDKY RVVYTDHQRL ELEKEFHYSR YITIRRKAEL AAALGLTERQ
VKIWFQNRRA KERKVNKKKL QQQSQPTSTT TPTPPAVGTP GPMGTLCSGS APSLVSSSPL
TIKEEFMP
