ID   HMD2_CHICK              Reviewed;          60 AA.
AC   Q02814;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Homeobox protein CHOX-CAD2;
DE   Flags: Fragment;
GN   Name=CHOX-CAD2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Embryo;
RX   PubMed=7678491; DOI=10.1006/bbrc.1993.1041;
RA   Serrano J., Scavo L., Roth J., la Rosa E.J., de Pablo F.;
RT   "A novel chicken homeobox-containing gene expressed in neurulating
RT   embryos.";
RL   Biochem. Biophys. Res. Commun. 190:270-276(1993).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late gastrulation and early
CC       neurulation.
CC   -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
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DR   EMBL; L06621; AAA48999.1; -; mRNA.
DR   PIR; PC1228; PC1228.
DR   AlphaFoldDB; Q02814; -.
DR   SMR; Q02814; -.
DR   STRING; 9031.ENSGALP00000012387; -.
DR   PaxDb; Q02814; -.
DR   VEuPathDB; HostDB:geneid_374205; -.
DR   eggNOG; KOG0848; Eukaryota.
DR   InParanoid; Q02814; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..>60
FT                   /note="Homeobox protein CHOX-CAD2"
FT                   /id="PRO_0000049019"
FT   DNA_BIND        1..60
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         60
SQ   SEQUENCE   60 AA;  7492 MW;  2FD0CAC37AAF5C4B CRC64;
     KEKYRVVYTD HQRLELEKEF HCNRYITIRR KSELAVNLGL SERQVKSWFQ NRRAKERKII