ID   HMDX_METJA              Reviewed;         338 AA.
AC   Q58125;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ0715;
GN   OrderedLocusNames=MJ0715;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the HMD family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98710.1; -; Genomic_DNA.
DR   PIR; C64389; C64389.
DR   RefSeq; WP_010870221.1; NC_000909.1.
DR   PDB; 4YTE; X-ray; 2.15 A; A=1-194.
DR   PDBsum; 4YTE; -.
DR   AlphaFoldDB; Q58125; -.
DR   SMR; Q58125; -.
DR   STRING; 243232.MJ_0715; -.
DR   EnsemblBacteria; AAB98710; AAB98710; MJ_0715.
DR   GeneID; 1451593; -.
DR   KEGG; mja:MJ_0715; -.
DR   eggNOG; arCOG03195; Archaea.
DR   HOGENOM; CLU_069755_0_0_2; -.
DR   OMA; INAPKDM; -.
DR   OrthoDB; 49901at2157; -.
DR   PhylomeDB; Q58125; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1300; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR004889; HMD_C.
DR   InterPro; IPR038182; HMD_C_sf.
DR   InterPro; IPR010063; HMDII/III.
DR   InterPro; IPR024190; METHMP_Hmd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF03201; HMD; 1.
DR   PIRSF; PIRSF016158; HMD; 1.
DR   PIRSF; PIRSF500166; HMDII_III; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01724; hmd_rel; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Oxidoreductase; Reference proteome.
FT   CHAIN           1..338
FT                   /note="H(2)-forming methylenetetrahydromethanopterin
FT                   dehydrogenase-related protein MJ0715"
FT                   /id="PRO_0000218517"
FT   STRAND          2..6
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           11..16
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           20..23
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           31..41
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          45..49
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           53..55
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           58..66
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          70..73
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           75..79
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          83..87
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           95..102
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   TURN            103..105
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          111..116
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           120..125
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           128..133
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          139..142
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          144..147
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          156..162
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   HELIX           172..184
FT                   /evidence="ECO:0007829|PDB:4YTE"
FT   STRAND          188..193
FT                   /evidence="ECO:0007829|PDB:4YTE"
SQ   SEQUENCE   338 AA;  36854 MW;  339B264EA44B013B CRC64;
     MKISIYGAGN QRLYLEQLKV PEKFGGEPPY GGAGMAIEFA KAGHDVVLSE PNRDVMSDDL
     WKKVEDAGVK VVSDDIEAAK HGEIHVLFTP FGRITLNIAN TIIEHVPENA IICNTCTIPT
     PVLYRSLEGI LRLKRRDVGI SSMHPTGVPG TPSQKYYTIA GKALEGKEYA TEDQINKLVE
     LVKSVGKIPY VTPADVVPAV ADMGALVTAV ALVGVLDYYR VGTQIINAPK DMIEKQILIS
     LQTIASIIET SGMEGLMKVF NKDALLSSAK NMLIDERQED LNLALKIIEE FDKSTIGEKD
     ISQTYLVAPQ ALIKEAVSLI GKSAVEGMIR RSSNKLFK