ID   HMD_METM5               Reviewed;         354 AA.
AC   A4G064;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=5,10-methenyltetrahydromethanopterin hydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE            EC=1.12.98.2 {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=H(2)-dependent methylene-H(4)MPT dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=N(5),N(10)-methenyltetrahydromethanopterin hydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
GN   Name=hmd {ECO:0000255|HAMAP-Rule:MF_01090}; OrderedLocusNames=MmarC5_1551;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC       methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_01090}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-
CC         methylenetetrahydromethanopterin + H(+); Xref=Rhea:RHEA:20017,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:18276, ChEBI:CHEBI:57818,
CC         ChEBI:CHEBI:58337; EC=1.12.98.2; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01090};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC       tetrahydromethanopterin (hydrogen route): step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_01090}.
CC   -!- SIMILARITY: Belongs to the HMD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01090}.
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DR   EMBL; CP000609; ABO35848.1; -; Genomic_DNA.
DR   RefSeq; WP_011869295.1; NC_009135.1.
DR   AlphaFoldDB; A4G064; -.
DR   SMR; A4G064; -.
DR   STRING; 402880.MmarC5_1551; -.
DR   EnsemblBacteria; ABO35848; ABO35848; MmarC5_1551.
DR   GeneID; 4929076; -.
DR   KEGG; mmq:MmarC5_1551; -.
DR   eggNOG; arCOG03196; Archaea.
DR   HOGENOM; CLU_772960_0_0_2; -.
DR   OMA; HACTIPT; -.
DR   OrthoDB; 31540at2157; -.
DR   UniPathway; UPA00640; UER00696.
DR   Proteomes; UP000000253; Chromosome.
DR   GO; GO:0047068; F:N5,N10-methenyltetrahydromethanopterin hydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.1300; -; 1.
DR   HAMAP; MF_01090; HMD; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR010062; HMD.
DR   InterPro; IPR004889; HMD_C.
DR   InterPro; IPR038182; HMD_C_sf.
DR   InterPro; IPR024190; METHMP_Hmd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF03201; HMD; 1.
DR   PIRSF; PIRSF016158; HMD; 1.
DR   PIRSF; PIRSF500165; HMDI; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01723; hmd_TIGR; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; One-carbon metabolism; Oxidoreductase.
FT   CHAIN           1..354
FT                   /note="5,10-methenyltetrahydromethanopterin hydrogenase"
FT                   /id="PRO_1000149884"
SQ   SEQUENCE   354 AA;  37970 MW;  4C388C50EF785672 CRC64;
     MKVAILGAGC YRTHAASGIT NFSRAAQVAK EVGIPEITMT HSTITMGAEL LHLIPEITEV
     VVSDPCFAEE PGIVVLDQFD YKTVMEAHLA GDAEKVMPEI REAVKAKAKE TPKPPKGCIH
     FVHPETIGLK VTASDVEAVK NADIVITWLP KGGSQPAIIE KFVGAIKKGA IVTHACTIPT
     PKFAKIFKDM GRDDLNIIAY HPGAVPEMKG QAFLSEGLAD AEKVEEFYCM AKTARGEAFK
     MPANLISPVC DMGSAVTAPV YAGILAYRDA VTQILGAPAD FAQMMADEAI TQLLELMRSE
     GIKNMEDKLN PKALTGTADS MCFGPLADIL PTSLKVLEKH TNENKCECSC SIKP