ID   HMD_METM7               Reviewed;         354 AA.
AC   A6VIB6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=5,10-methenyltetrahydromethanopterin hydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE            EC=1.12.98.2 {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=H(2)-dependent methylene-H(4)MPT dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=N(5),N(10)-methenyltetrahydromethanopterin hydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
GN   Name=hmd {ECO:0000255|HAMAP-Rule:MF_01090}; OrderedLocusNames=MmarC7_1126;
OS   Methanococcus maripaludis (strain C7 / ATCC BAA-1331).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=426368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C7 / ATCC BAA-1331;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus maripaludis C7.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC       methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_01090}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-
CC         methylenetetrahydromethanopterin + H(+); Xref=Rhea:RHEA:20017,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:18276, ChEBI:CHEBI:57818,
CC         ChEBI:CHEBI:58337; EC=1.12.98.2; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01090};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC       tetrahydromethanopterin (hydrogen route): step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_01090}.
CC   -!- SIMILARITY: Belongs to the HMD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01090}.
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DR   EMBL; CP000745; ABR66192.1; -; Genomic_DNA.
DR   RefSeq; WP_011977504.1; NC_009637.1.
DR   AlphaFoldDB; A6VIB6; -.
DR   SMR; A6VIB6; -.
DR   STRING; 426368.MmarC7_1126; -.
DR   EnsemblBacteria; ABR66192; ABR66192; MmarC7_1126.
DR   GeneID; 5328494; -.
DR   KEGG; mmz:MmarC7_1126; -.
DR   eggNOG; arCOG03196; Archaea.
DR   HOGENOM; CLU_772960_0_0_2; -.
DR   OMA; HACTIPT; -.
DR   OrthoDB; 31540at2157; -.
DR   UniPathway; UPA00640; UER00696.
DR   GO; GO:0047068; F:N5,N10-methenyltetrahydromethanopterin hydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.1300; -; 1.
DR   HAMAP; MF_01090; HMD; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR010062; HMD.
DR   InterPro; IPR004889; HMD_C.
DR   InterPro; IPR038182; HMD_C_sf.
DR   InterPro; IPR024190; METHMP_Hmd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF03201; HMD; 1.
DR   PIRSF; PIRSF016158; HMD; 1.
DR   PIRSF; PIRSF500165; HMDI; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01723; hmd_TIGR; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; One-carbon metabolism; Oxidoreductase.
FT   CHAIN           1..354
FT                   /note="5,10-methenyltetrahydromethanopterin hydrogenase"
FT                   /id="PRO_1000149885"
SQ   SEQUENCE   354 AA;  37746 MW;  9EFC2CC8A2239A26 CRC64;
     MKVAILGAGC YRTHAASGIT NFSRAAQVAK EAGMPEIAMT HSTITMGAEL LHLIPEITEV
     VVSDPCFGEE PGMIVLDQFD YKAVMEAHLA GEAEKVMPEI RAAVTAKAKE TPKPPKGCIH
     FVHPETIGLK VTASDVEAVK DADIVITWLP KGGSQPAIIE KFASEIKKGA IVTHACTIPT
     PKFAKIFKDL GRDDLNIIAY HPGAVPENKG QAFLSEGLAD AEKVEEFYCI AKAARGEAFK
     MPAKLISPVC DMGSAVTAPV YAGILAYRDA VTQILGAPAD FAQMMADEAI TQLLDLMRSE
     GIKNMEDKLN PKALTGTADS MCFGPLADIL PASLKVLEKH ANENKCECGN SIKP