ID   HMD_METMP               Reviewed;         354 AA.
AC   Q6M0Z1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=5,10-methenyltetrahydromethanopterin hydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE            EC=1.12.98.2 {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=H(2)-dependent methylene-H(4)MPT dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
DE   AltName: Full=N(5),N(10)-methenyltetrahydromethanopterin hydrogenase {ECO:0000255|HAMAP-Rule:MF_01090};
GN   Name=hmd {ECO:0000255|HAMAP-Rule:MF_01090}; OrderedLocusNames=MMP0127;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC       methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_01090}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-
CC         methylenetetrahydromethanopterin + H(+); Xref=Rhea:RHEA:20017,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:18276, ChEBI:CHEBI:57818,
CC         ChEBI:CHEBI:58337; EC=1.12.98.2; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01090};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC       tetrahydromethanopterin (hydrogen route): step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_01090}.
CC   -!- SIMILARITY: Belongs to the HMD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01090}.
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DR   EMBL; BX950229; CAF29683.1; -; Genomic_DNA.
DR   RefSeq; WP_011170071.1; NC_005791.1.
DR   AlphaFoldDB; Q6M0Z1; -.
DR   SMR; Q6M0Z1; -.
DR   STRING; 267377.MMP0127; -.
DR   EnsemblBacteria; CAF29683; CAF29683; MMP0127.
DR   GeneID; 2761547; -.
DR   KEGG; mmp:MMP0127; -.
DR   PATRIC; fig|267377.15.peg.128; -.
DR   eggNOG; arCOG03196; Archaea.
DR   HOGENOM; CLU_772960_0_0_2; -.
DR   OMA; HACTIPT; -.
DR   OrthoDB; 31540at2157; -.
DR   BioCyc; MMAR267377:MMP_RS00735-MON; -.
DR   UniPathway; UPA00640; UER00696.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0047068; F:N5,N10-methenyltetrahydromethanopterin hydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.1300; -; 1.
DR   HAMAP; MF_01090; HMD; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR010062; HMD.
DR   InterPro; IPR004889; HMD_C.
DR   InterPro; IPR038182; HMD_C_sf.
DR   InterPro; IPR024190; METHMP_Hmd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF03201; HMD; 1.
DR   PIRSF; PIRSF016158; HMD; 1.
DR   PIRSF; PIRSF500165; HMDI; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01723; hmd_TIGR; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; One-carbon metabolism; Oxidoreductase; Reference proteome.
FT   CHAIN           1..354
FT                   /note="5,10-methenyltetrahydromethanopterin hydrogenase"
FT                   /id="PRO_1000149886"
SQ   SEQUENCE   354 AA;  37868 MW;  CB7C3413D38636EA CRC64;
     MKVAILGAGC YRTHAASGIT NFSRASQVAK EAGIPEIAMT HSTITMGAEL LHLIPEITEV
     VVSDPCFAEE PGMVVLDQFD YKAVMEAHLA GDAEKVMPEI REAVKAKAKE TPKPPKGCIH
     FVHPETVGLK VTASDVEAVK DADIVITWLP KGGSQPAIIE KFASEIKKGA IVTHACTIPT
     PKFAKIFKDL GRDDLNIIAY HPGAVPEMKG QAFLSEGLAD AEKVEEFYCM AKTARGEAFK
     MPANLISPVC DMGSAVTAPV YAAILAYRDA VTQILGAPAD FAQMMADEAI SQILDLMRNE
     GIKNMEDKLN PKALTGTADS MCFGPLADIL PASLKVLEKH ANENKCECGC SIKP