HME1A_DANRE
ID HME1A_DANRE Reviewed; 231 AA.
AC Q04896;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Homeobox protein engrailed-1a;
DE Short=Homeobox protein en-1a;
GN Name=eng1a; Synonyms=eng-1, eng1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1363539; DOI=10.1242/dev.116.4.1001;
RA Ekker M., Wegner J., Akimenko M.-A., Westerfield M.;
RT "Coordinate embryonic expression of three zebrafish engrailed genes.";
RL Development 116:1001-1010(1992).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR EMBL; X68445; CAA48490.1; -; mRNA.
DR PIR; S30438; S30438.
DR RefSeq; NP_571120.1; NM_131045.1.
DR AlphaFoldDB; Q04896; -.
DR SMR; Q04896; -.
DR STRING; 7955.ENSDARP00000023487; -.
DR PaxDb; Q04896; -.
DR GeneID; 30244; -.
DR KEGG; dre:30244; -.
DR CTD; 30244; -.
DR ZFIN; ZDB-GENE-980526-216; en1a.
DR eggNOG; KOG0493; Eukaryota.
DR InParanoid; Q04896; -.
DR OrthoDB; 1575614at2759; -.
DR PRO; PR:Q04896; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060385; P:axonogenesis involved in innervation; IGI:ZFIN.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR019737; Homoebox-engrailed_CS.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF10525; Engrail_1_C_sig; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00033; ENGRAILED; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..231
FT /note="Homeobox protein engrailed-1a"
FT /id="PRO_0000196072"
FT DNA_BIND 143..202
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 26200 MW; 91BA2674ED886455 CRC64;
MEDQRRGQGE EEDDSGSLPS PPLLPAHRNT DFFIDNILRP DFGCKRERER VTRDSGVRPT
ALPDSRSDGV SSSASSTVSS PVSSRQSNKV EQGSSKSSSP SKDSQKQILW PAWVYCTRYS
DRPSSGPRTR KLKKKNNNTE SDDKRPRTAF TAEQLQRLKA EFQTSRYITE QRRQALAREL
GLNESQIKIW FQNKRAKIKK SSGFKNALAM QLMAQGLYNH STTTIQEEED N
