HME1A_XENLA
ID HME1A_XENLA Reviewed; 60 AA.
AC P31537;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Homeobox protein engrailed-1-A;
DE Short=En-1A;
DE Short=Homeobox protein en-1-A;
DE Flags: Fragment;
GN Name=en1-a; Synonyms=en1a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1980115; DOI=10.1016/0014-5793(90)80858-g;
RA Holland P.W.H., Williams N.A.;
RT "Conservation of engrailed-like homeobox sequences during vertebrate
RT evolution.";
RL FEBS Lett. 277:250-252(1990).
CC -!- FUNCTION: Required for proper formation of the apical ectodermal ridge
CC and correct dorsal-ventral patterning in the limb.
CC {ECO:0000250|UniProtKB:P09065}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR EMBL; X59123; CAA41845.1; ALT_TERM; Genomic_DNA.
DR PIR; S13010; S13010.
DR AlphaFoldDB; P31537; -.
DR SMR; P31537; -.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN <1..>60
FT /note="Homeobox protein engrailed-1-A"
FT /id="PRO_0000196065"
FT DNA_BIND <1..41
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT NON_TER 1
FT NON_TER 60
SQ SEQUENCE 60 AA; 7041 MW; E5D8A9F3768699AE CRC64;
AEQLQRLKAE FQANRYITEQ RRQSLAQELS LNESQIKIWF QNKRAKIKKA SGMKNGLALH