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HME1A_XENLA
ID   HME1A_XENLA             Reviewed;          60 AA.
AC   P31537;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Homeobox protein engrailed-1-A;
DE            Short=En-1A;
DE            Short=Homeobox protein en-1-A;
DE   Flags: Fragment;
GN   Name=en1-a; Synonyms=en1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1980115; DOI=10.1016/0014-5793(90)80858-g;
RA   Holland P.W.H., Williams N.A.;
RT   "Conservation of engrailed-like homeobox sequences during vertebrate
RT   evolution.";
RL   FEBS Lett. 277:250-252(1990).
CC   -!- FUNCTION: Required for proper formation of the apical ectodermal ridge
CC       and correct dorsal-ventral patterning in the limb.
CC       {ECO:0000250|UniProtKB:P09065}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; X59123; CAA41845.1; ALT_TERM; Genomic_DNA.
DR   PIR; S13010; S13010.
DR   AlphaFoldDB; P31537; -.
DR   SMR; P31537; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..>60
FT                   /note="Homeobox protein engrailed-1-A"
FT                   /id="PRO_0000196065"
FT   DNA_BIND        <1..41
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         60
SQ   SEQUENCE   60 AA;  7041 MW;  E5D8A9F3768699AE CRC64;
     AEQLQRLKAE FQANRYITEQ RRQSLAQELS LNESQIKIWF QNKRAKIKKA SGMKNGLALH
 
 
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