ID   HME1B_XENLA             Reviewed;         171 AA.
AC   P31538;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Homeobox protein engrailed-1-B;
DE            Short=En-1B;
DE            Short=Homeobox protein en-1-B;
DE   Flags: Fragment;
GN   Name=en1-b; Synonyms=en1b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8099437; DOI=10.1093/nar/21.10.2513;
RA   Watanabe M., Hayashida T., Nishimoto T., Kobayashi H.;
RT   "Nucleotide sequence of Xenopus homeobox gene, En-1.";
RL   Nucleic Acids Res. 21:2513-2513(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-150.
RX   PubMed=1980115; DOI=10.1016/0014-5793(90)80858-g;
RA   Holland P.W.H., Williams N.A.;
RT   "Conservation of engrailed-like homeobox sequences during vertebrate
RT   evolution.";
RL   FEBS Lett. 277:250-252(1990).
CC   -!- FUNCTION: Required for proper formation of the apical ectodermal ridge
CC       and correct dorsal-ventral patterning in the limb.
CC       {ECO:0000250|UniProtKB:P09065}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; D14693; BAA03519.1; -; mRNA.
DR   EMBL; X59124; CAA41846.1; ALT_TERM; Genomic_DNA.
DR   PIR; S35638; S35638.
DR   AlphaFoldDB; P31538; -.
DR   SMR; P31538; -.
DR   PRIDE; P31538; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..171
FT                   /note="Homeobox protein engrailed-1-B"
FT                   /id="PRO_0000196066"
FT   DNA_BIND        82..141
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   171 AA;  19151 MW;  7ABB925B92D25FEC CRC64;
     EDPGTMGPGN PAPSPDSDTP SDSSKGSDSN PALLLVGNAA PPVHKKDSVV WPAWVYCTRY
     SDRPSSGPRT RKLKKKKSEK EDKRPRTAFT AEQLQRLKAE FQANRYITEQ RRQTLAQELS
     LNESQIKIWF QNKRAKIKKA SGMKNGLALH LMAQGLYNHS TTTVQEKEES E