ID   HME1_CHICK              Reviewed;         333 AA.
AC   Q05916;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Homeobox protein engrailed-1;
DE            Short=Gg-En-1;
DE            Short=Homeobox protein en-1;
GN   Name=EN1; Synonyms=EN-1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1363401; DOI=10.1002/dvg.1020130505;
RA   Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J.,
RA   Joyner A.L.;
RT   "Cloning and sequence comparison of the mouse, human, and chicken engrailed
RT   genes reveal potential functional domains and regulatory regions.";
RL   Dev. Genet. 13:345-358(1992).
CC   -!- FUNCTION: Required for proper formation of the apical ectodermal ridge
CC       and correct dorsal-ventral patterning in the limb.
CC       {ECO:0000250|UniProtKB:P09065}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; L12694; AAA53435.1; -; Genomic_DNA.
DR   EMBL; L12695; AAA53436.1; -; Genomic_DNA.
DR   PIR; C48423; C48423.
DR   AlphaFoldDB; Q05916; -.
DR   SMR; Q05916; -.
DR   STRING; 9031.ENSGALP00000041310; -.
DR   PaxDb; Q05916; -.
DR   VEuPathDB; HostDB:geneid_771008; -.
DR   eggNOG; KOG0493; Eukaryota.
DR   InParanoid; Q05916; -.
DR   PhylomeDB; Q05916; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..333
FT                   /note="Homeobox protein engrailed-1"
FT                   /id="PRO_0000196064"
FT   DNA_BIND        244..303
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..68
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  34516 MW;  D0F1B1F917E1FBAD CRC64;
     MEEPPEGHGH HRDAAPPGPA NGGGGGGGGS DGDSAPVSPS PAPASPAAPC PLPLPRRRPP
     PPPPPRTTNF FIDNILRPDF GCKKEPPAAT GAATGAGGGG GGGGREQRDG AQSAGRENVN
     PLLARPPHAP SSALLCPDSN CAPDGSAPAG TAAKANPGTA AGAAGAAGAA KAQGDGGETP
     AAKYGEHGSP AILLMGSNNG GAVLKPDSQQ PLVWPAWVYC TRYSDRPSSP RTRKLKKKKT
     EKEDKRPRTA FTAEQLQRLK AEFQANRYIT EQRRQSLAQE LSLNESRVKI WFQNKRAKIK
     KATGIKNGLA LHLMAQGLYN HSTTTVQDKE ESE