HME2A_XENLA
ID HME2A_XENLA Reviewed; 265 AA.
AC P52729;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Homeobox protein engrailed-2-A;
DE Short=En-2A;
DE Short=Homeobox protein en-2-A;
DE AltName: Full=En2 1.4;
GN Name=en2-a; Synonyms=en2a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Head;
RX PubMed=1679005; DOI=10.1242/dev.111.3.715;
RA Hemmati-Brivanlou A., de la Torre J.R., Holt C., Harland R.M.;
RT "Cephalic expression and molecular characterization of Xenopus En-2.";
RL Development 111:715-724(1991).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: In addition to the main band of expression at the
CC midbrain-hindbrain boundary, the protein is expressed in the mandibular
CC arch, the optic tectum and the region of anterior pituitary.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR EMBL; X62973; CAA44723.1; -; mRNA.
DR PIR; S19004; S19004.
DR RefSeq; NP_001095213.1; NM_001101743.1.
DR AlphaFoldDB; P52729; -.
DR SMR; P52729; -.
DR GeneID; 378588; -.
DR KEGG; xla:378588; -.
DR CTD; 378588; -.
DR Xenbase; XB-GENE-866462; en2.L.
DR OMA; RENGDQC; -.
DR OrthoDB; 1575614at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 378588; Expressed in neurula embryo and 1 other tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR019737; Homoebox-engrailed_CS.
DR Pfam; PF10525; Engrail_1_C_sig; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00033; ENGRAILED; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..265
FT /note="Homeobox protein engrailed-2-A"
FT /id="PRO_0000196070"
FT DNA_BIND 176..235
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 29897 MW; B036E37F62826E7D CRC64;
MEENEQNNRE VEPQQESGEE SNRGILHQAP PGNHQPHHRI TNFFIDNILR PEFGRRKEGI
SHQDELYTER DTGALSGAES GHHRVNVPEG AGGSSKVITV TGEKKSDLAM EETLKSRGLN
GDHSLSSDSD SSQTSSKATQ QPMLWPAWVY CTRYSDRPSS GPRSRKPKKK SVSKEDKRPR
TAFTADQLQR LKAEFQTNRY LTEQRRQSLA QELSLNESQI KIWFQNKRAK IKKATGNKNS
LALHLMAQGL YNHSTTSKDG KSDSE
