3SOFV_NAJAT
ID 3SOFV_NAJAT Reviewed; 83 AA.
AC Q9W716;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Cytotoxin homolog 5V;
DE AltName: Full=Cardiotoxin-5V;
DE Short=CTX5V {ECO:0000312|EMBL:CAB50697.1};
DE Flags: Precursor;
OS Naja atra (Chinese cobra).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=8656;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RA Qian Y.-C., Fang C.-Y., Gong Y., Yang S.-L.;
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has low cytotoxic activity. {ECO:0000250|UniProtKB:P14541}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P62375}. Target
CC cell membrane {ECO:0000250|UniProtKB:P62375}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC residue stands at position 52 (Pro-31 in standard classification).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ007765; CAB50697.1; -; mRNA.
DR AlphaFoldDB; Q9W716; -.
DR SMR; Q9W716; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:InterPro.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003572; Cytotoxin_Cobra.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR InterPro; IPR035076; Toxin/TOLIP.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR PRINTS; PR00282; CYTOTOXIN.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 3: Inferred from homology;
KW Cytolysis; Disulfide bond; Membrane; Secreted; Signal;
KW Target cell membrane; Target membrane.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..83
FT /note="Cytotoxin homolog 5V"
FT /id="PRO_0000035378"
FT DISULFID 24..43
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 36..61
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 65..76
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 77..82
FT /evidence="ECO:0000250|UniProtKB:P60301"
SQ SEQUENCE 83 AA; 9333 MW; 34D380E7A0F851DD CRC64;
MKTLLLTLVV VTIVCLDLGY TLKCHNTQLP FIYKTCPEGK NLCFKATLRK FPLKFPVKRG
CADNCPKNSA LLKYVCCSTD KCN