HME2_CHICK
ID HME2_CHICK Reviewed; 289 AA.
AC Q05917;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2012, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Homeobox protein engrailed-2;
DE Short=Gg-En-2;
DE Short=Homeobox protein en-2;
GN Name=EN2; Synonyms=EN-2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1363401; DOI=10.1002/dvg.1020130505;
RA Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J.,
RA Joyner A.L.;
RT "Cloning and sequence comparison of the mouse, human, and chicken engrailed
RT genes reveal potential functional domains and regulatory regions.";
RL Dev. Genet. 13:345-358(1992).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA53437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAA53438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; L12696; AAA53437.1; ALT_SEQ; Genomic_DNA.
DR EMBL; L12697; AAA53438.1; ALT_SEQ; Genomic_DNA.
DR PIR; F48423; F48423.
DR RefSeq; NP_001254648.1; NM_001267719.1.
DR PDB; 3ZOB; NMR; -; A=200-259.
DR PDBsum; 3ZOB; -.
DR AlphaFoldDB; Q05917; -.
DR BMRB; Q05917; -.
DR SMR; Q05917; -.
DR STRING; 9031.ENSGALP00000042412; -.
DR Ensembl; ENSGALT00000075534; ENSGALP00000045557; ENSGALG00000041295.
DR GeneID; 100859435; -.
DR KEGG; gga:100859435; -.
DR CTD; 2020; -.
DR VEuPathDB; HostDB:geneid_100859435; -.
DR eggNOG; KOG0493; Eukaryota.
DR GeneTree; ENSGT00940000159935; -.
DR HOGENOM; CLU_051739_2_0_1; -.
DR InParanoid; Q05917; -.
DR OMA; PLPXAGS; -.
DR OrthoDB; 1575614at2759; -.
DR PRO; PR:Q05917; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000041295; Expressed in cerebellum and 1 other tissue.
DR ExpressionAtlas; Q05917; baseline.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IDA:UniProtKB.
DR GO; GO:0030426; C:growth cone; IDA:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; IDA:UniProtKB.
DR GO; GO:0043005; C:neuron projection; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IDA:UniProtKB.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; IEA:Ensembl.
DR GO; GO:1990403; P:embryonic brain development; IEA:Ensembl.
DR GO; GO:0030902; P:hindbrain development; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1901215; P:negative regulation of neuron death; IGI:ParkinsonsUK-UCL.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR DisProt; DP01779; -.
DR InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR019737; Homoebox-engrailed_CS.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF10525; Engrail_1_C_sig; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00033; ENGRAILED; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome.
FT CHAIN 1..289
FT /note="Homeobox protein engrailed-2"
FT /id="PRO_0000196069"
FT DNA_BIND 200..259
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 203..206
FT /evidence="ECO:0007829|PDB:3ZOB"
FT HELIX 209..221
FT /evidence="ECO:0007829|PDB:3ZOB"
FT TURN 227..229
FT /evidence="ECO:0007829|PDB:3ZOB"
FT HELIX 230..236
FT /evidence="ECO:0007829|PDB:3ZOB"
FT HELIX 241..252
FT /evidence="ECO:0007829|PDB:3ZOB"
FT STRAND 254..256
FT /evidence="ECO:0007829|PDB:3ZOB"
SQ SEQUENCE 289 AA; 30507 MW; C5EF48F9F160AA2A CRC64;
MEEGGRSPRE EAAEPQESGG DAEPGGGRRA LLLPPGDPPH PHPHPHRITN FFIDNILRPE
FGRRKEAGGT AGEPRRPGAE SRRSPAAAAP APGAPVPGGG GGGGGGSPGR GEGGPAALAL
HGAAKKGGDP AALEAALKAR GLSGAELSVS SDSDSSQAGS NAGNQPMLWP AWVYCTRYSD
RPSSGPRSRK PKKKNPNKED KRPRTAFTAE QLQRLKAEFQ TNRYLTEQRR QSLAQELGLN
ESQIKIWFQN KRAKIKKATG SKNSLAVHLM AQGLYNHSTT AKDGKSDSE
