ID   HME30_APIME             Reviewed;         109 AA.
AC   P09076;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 3.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Homeobox protein E30;
DE   Flags: Fragment;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2574865; DOI=10.1073/pnas.86.24.9971;
RA   Walldorf U., Fleig R., Gehring W.J.;
RT   "Comparison of homeobox-containing genes of the honeybee and Drosophila.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9971-9975(1989).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; M29490; AAA27725.1; -; Genomic_DNA.
DR   PIR; E34510; E34510.
DR   AlphaFoldDB; P09076; -.
DR   SMR; P09076; -.
DR   STRING; 7460.GB55322-PA; -.
DR   PaxDb; P09076; -.
DR   PRIDE; P09076; -.
DR   eggNOG; KOG0493; Eukaryota.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..>109
FT                   /note="Homeobox protein E30"
FT                   /id="PRO_0000196083"
FT   DNA_BIND        20..79
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         109
SQ   SEQUENCE   109 AA;  12626 MW;  EE47260F0FA6F60D CRC64;
     GPRTRRVKRS HNGKNGSPEE KRPRTAFSAE QLARLKREFA ENRYLTERRR QQLSRDLGLT
     EAQIKIWFQN KRAKIKKASG QKNPLALQLM AQGLYNHSTV PVDEDGEEI