ID   HMEB_ARCFU              Reviewed;         395 AA.
AC   O29750;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Hdr-like menaquinol oxidoreductase integral membrane subunit;
DE            Short=Hme subunit B;
GN   Name=hmeB; OrderedLocusNames=AF_0500;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=11952791; DOI=10.1046/j.1432-1033.2002.02839.x;
RA   Mander G.J., Duin E.C., Linder D., Stetter K.O., Hedderich R.;
RT   "Purification and characterization of a membrane-bound enzyme complex from
RT   the sulfate-reducing archaeon Archaeoglobus fulgidus related to
RT   heterodisulfide reductase from methanogenic archaea.";
RL   Eur. J. Biochem. 269:1895-1904(2002).
CC   -!- FUNCTION: Has menaquinol-oxidizing activity. HmeB subunit may function
CC       as a menaquinol-oxidizing site. HmeA, HmeB and HmeE subunits may
CC       together catalyze electron transfer from menaquinol to cytochrome c.
CC   -!- SUBUNIT: Consists of five subunits: an integral membrane subunit, a
CC       cytochrome b-like subunit, a cytochrome c subunit and two iron-sulfur
CC       subunits.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NrfD family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90737.1; -; Genomic_DNA.
DR   PIR; D69312; D69312.
DR   RefSeq; WP_010878007.1; NC_000917.1.
DR   AlphaFoldDB; O29750; -.
DR   SMR; O29750; -.
DR   STRING; 224325.AF_0500; -.
DR   EnsemblBacteria; AAB90737; AAB90737; AF_0500.
DR   GeneID; 24794040; -.
DR   KEGG; afu:AF_0500; -.
DR   eggNOG; arCOG02025; Archaea.
DR   HOGENOM; CLU_045348_3_1_2; -.
DR   OMA; WNASILA; -.
DR   OrthoDB; 101534at2157; -.
DR   PhylomeDB; O29750; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR005614; NrfD_fam.
DR   Pfam; PF03916; NrfD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Electron transport; Membrane; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..395
FT                   /note="Hdr-like menaquinol oxidoreductase integral membrane
FT                   subunit"
FT                   /id="PRO_0000159324"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  44195 MW;  B8622ADFC9EB9F23 CRC64;
     MAVEFKKIEG DSIQYFALVI ILAAVTALGF YAYVLDHKMG LNGLSNRVPW GIVNAGIPYF
     IGLSAGSLIV SALAGVFNIK KYKVFSRIAA YMAAAWIIAA ILSIALDIGK LYHFMNAVRY
     FNPTSIFSWN AFLYSSYFVI CSIYLLVQFE EMEKATRFMA GLAVFWAVLV HSGTGAIYSF
     VYSKELYHSA LTPPMFIVCA ITSGLGLLLA NLYFTFRFTK RELDPKLIRG LALIFAGLMM
     VLGYFLAVEG LEKGYIPALH EAVQFVFLTP TSGVFWSFWL LVIFGIAIPI IIVLNPKTGY
     DLRWITFAGI LHAALVFAER FYLIIPGQVF PEEYLPGYEL ESLHTLEGYI VSYTPSVFEW
     LQVIGLIAMV YLIFVVGVKL FALIPERAVE EVVEE