ID   HMEC_ARCFU              Reviewed;         332 AA.
AC   O29749;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Hdr-like menaquinol oxidoreductase cytochrome b-like subunit;
DE            Short=Hme subunit C;
GN   Name=hmeC; OrderedLocusNames=AF_0501;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-15.
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=11952791; DOI=10.1046/j.1432-1033.2002.02839.x;
RA   Mander G.J., Duin E.C., Linder D., Stetter K.O., Hedderich R.;
RT   "Purification and characterization of a membrane-bound enzyme complex from
RT   the sulfate-reducing archaeon Archaeoglobus fulgidus related to
RT   heterodisulfide reductase from methanogenic archaea.";
RL   Eur. J. Biochem. 269:1895-1904(2002).
CC   -!- FUNCTION: Has menaquinol-oxidizing activity. HmeC and HmeD subunits may
CC       together mediate electron transfer from menaquinol to an unidentified
CC       electron acceptor on the cytoplasmic side of the membrane.
CC   -!- SUBUNIT: Consists of five subunits: an integral membrane subunit, a
CC       cytochrome b-like subunit, a cytochrome c subunit and two iron-sulfur
CC       subunits.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000782; AAB90736.1; -; Genomic_DNA.
DR   PIR; E69312; E69312.
DR   RefSeq; WP_010878008.1; NC_000917.1.
DR   AlphaFoldDB; O29749; -.
DR   STRING; 224325.AF_0501; -.
DR   PRIDE; O29749; -.
DR   EnsemblBacteria; AAB90736; AAB90736; AF_0501.
DR   GeneID; 24794041; -.
DR   KEGG; afu:AF_0501; -.
DR   eggNOG; arCOG02194; Archaea.
DR   HOGENOM; CLU_067516_0_0_2; -.
DR   OMA; IPTTCGQ; -.
DR   OrthoDB; 88021at2157; -.
DR   PhylomeDB; O29749; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR023234; NarG-like_domain.
DR   InterPro; IPR036197; NarG-like_sf.
DR   Pfam; PF02665; Nitrate_red_gam; 1.
DR   SUPFAM; SSF103501; SSF103501; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Electron transport; Membrane;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..332
FT                   /note="Hdr-like menaquinol oxidoreductase cytochrome b-like
FT                   subunit"
FT                   /id="PRO_0000084006"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        11
FT                   /note="P -> F (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   332 AA;  38386 MW;  A5A4E82663469651 CRC64;
     MIGVIFGVIV PYIAVAIFVI GVIYRIVNWA NSAVPLKIPT TGGQQKSFPF IKRTIYDRFD
     SPYTWWETAG RMLLEIFFFR SLLKNTRYYL DRVSQKDARW LWLFGILFHY SLLLVLIRHS
     RFFLDPVPSF VETLSEIEAF KGVFIPSVYM SGLAIVAALF LLWLRRIFLS RERTLSLPSD
     HFALILLLAI TISGNVMRYF VKADLFAVKE LLMSLMTFNI GHAVEVANTI EPIFYVHFAL
     ASFLLAYFPF SKLMHAGGVF FSPTRNMPND NRARRHVNPW DPADVPLLAK GITVAGRVYK
     SKKLDWDTYY SMYTDQLQEI EEADYKIVPE EL