ID   HMEC_ARCPA              Reviewed;         336 AA.
AC   P84628; D2RF80;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Hdr-like menaquinol oxidoreductase cytochrome b-like subunit;
DE            Short=Hme subunit C;
GN   Name=hmeC; OrderedLocusNames=Arcpr_1729;
OS   Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=572546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5631 / JCM 9629 / NBRC 100127 / Av18;
RX   PubMed=21304717; DOI=10.4056/sigs.942153;
RA   von Jan M., Lapidus A., Del Rio T.G., Copeland A., Tice H., Cheng J.F.,
RA   Lucas S., Chen F., Nolan M., Goodwin L., Han C., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Chertkov O., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Saunders E.,
RA   Brettin T., Detter J.C., Chain P., Eichinger K., Huber H., Spring S.,
RA   Rohde M., Goker M., Wirth R., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Archaeoglobus profundus type strain (AV18).";
RL   Stand. Genomic Sci. 2:327-346(2010).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 2-21, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15009189; DOI=10.1111/j.1432-1033.2004.04013.x;
RA   Mander G.J., Pierik A.J., Huber H., Hedderich R.;
RT   "Two distinct heterodisulfide reductase-like enzymes in the sulfate-
RT   reducing archaeon Archaeoglobus profundus.";
RL   Eur. J. Biochem. 271:1106-1116(2004).
CC   -!- FUNCTION: Has menaquinol-oxidizing activity. The HmeC and HmeD subunits
CC       may together mediate electron transfer from menaquinol to an
CC       unidentified electron acceptor on the cytoplasmic side of the membrane.
CC       {ECO:0000269|PubMed:15009189}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15009189};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:15009189}.
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DR   EMBL; CP001857; ADB58774.1; -; Genomic_DNA.
DR   RefSeq; WP_012941109.1; NC_013741.1.
DR   AlphaFoldDB; P84628; -.
DR   STRING; 572546.Arcpr_1729; -.
DR   EnsemblBacteria; ADB58774; ADB58774; Arcpr_1729.
DR   GeneID; 8740423; -.
DR   KEGG; apo:Arcpr_1729; -.
DR   eggNOG; arCOG02194; Archaea.
DR   HOGENOM; CLU_067516_0_0_2; -.
DR   OMA; IPTTCGQ; -.
DR   OrthoDB; 88021at2157; -.
DR   Proteomes; UP000001901; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR023234; NarG-like_domain.
DR   InterPro; IPR036197; NarG-like_sf.
DR   Pfam; PF02665; Nitrate_red_gam; 1.
DR   SUPFAM; SSF103501; SSF103501; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Electron transport; Membrane;
KW   Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..336
FT                   /note="Hdr-like menaquinol oxidoreductase cytochrome b-like
FT                   subunit"
FT                   /id="PRO_0000150086"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        2
FT                   /note="S -> L (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   336 AA;  39268 MW;  F53B802FC3E5AC39 CRC64;
     MSEALYIFYA LPYICFAIFV IGTIYRVVDW ARSAVPLKIP TTSAQQPSFK FVRRTWIDKI
     DSPSSKFWAF VRVLFVVFLF RDLFRNTRYY IEMGGKNVDT RWLWLFAILF HYSLLVIVIR
     HLRFFTNPVP DFVKTLEYLD GVLGVAIVPP LLMTGVIALV ALAFLWGRRI LLAKERSISI
     PSDHLILFFM AVILVSGLLM RYIIKADLSY VKMFALSVVT FQPPSPEVLA NLHWLFLIHF
     TFVCITIAYI PFSKVMHFAG VWFSPTRNMP NDNRRKRHVN PWDPNPELPI LVREGITVAG
     VTYKCKKLDW DTYYEMYKDQ LDEIAEKNYT LKAEEF