HMEN_ARTSF
ID HMEN_ARTSF Reviewed; 349 AA.
AC Q05640;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Homeobox protein engrailed;
OS Artemia franciscana (Brine shrimp) (Artemia sanfranciscana).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Anostraca; Artemiidae; Artemia.
OX NCBI_TaxID=6661;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7903633; DOI=10.1242/dev.118.4.1209;
RA Manzanares M., Marco R., Garesse R.;
RT "Genomic organization and developmental pattern of expression of the
RT engrailed gene from the brine shrimp Artemia.";
RL Development 118:1209-1219(1993).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR EMBL; X70939; CAA50279.1; -; mRNA.
DR PIR; S32040; S32040.
DR AlphaFoldDB; Q05640; -.
DR SMR; Q05640; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR019737; Homoebox-engrailed_CS.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF10525; Engrail_1_C_sig; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00033; ENGRAILED; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus.
FT CHAIN 1..349
FT /note="Homeobox protein engrailed"
FT /id="PRO_0000196084"
FT DNA_BIND 249..308
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 26..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 39142 MW; B634D79A16E51EDB CRC64;
MGSAIFEPGP LSLLNLACSN LTERYDGPSP LSASTPGPSP DRPGSATMSS PLSSPTGISY
QSLLSGILPA AMFPYGYPPV GYMYPTGFPT LAAIQSGHLA FRQLVPTLPF NTVKSSEGQV
KEVVSTQSQK KPLAFSIDSI LRPDFGKETN EVKRRHASPH REEPKKKVQY IEQMKKKEEI
KEEARTESRL SSSSKDSVPD NDKINPPLPP EASKWPAWVF CTRYSDRPSS GRSPRCRRMK
KDKAITPDEK RPRTAFTAEQ LSRLKHEFNE NRYLTERRRQ DLARELGLHE NQIKIWFQNN
RAKLKKSSGQ KNPLALQLMA QGLYNHSTIP TEDDEDDEIS STSLQARIE
