ID   HMEN_BOMMO              Reviewed;         372 AA.
AC   P27609;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Segmentation polarity homeobox protein engrailed;
GN   Name=en;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Kinshu X Showa; TISSUE=Middle silk gland;
RX   PubMed=1346065; DOI=10.1073/pnas.89.1.167;
RA   Hui C.-C., Matsuno K., Ueno K., Suzuki Y.;
RT   "Molecular characterization and silk gland expression of Bombyx engrailed
RT   and invected genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:167-171(1992).
CC   -!- FUNCTION: This protein might be involved in the compartmentalization of
CC       the silk gland.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in the middle silk gland but not in the
CC       posterior silk gland during the fourth molt/fifth intermolt period.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; M64335; AAA62704.1; -; mRNA.
DR   PIR; A41792; A41792.
DR   RefSeq; NP_001037550.1; NM_001044085.1.
DR   AlphaFoldDB; P27609; -.
DR   SMR; P27609; -.
DR   STRING; 7091.BGIBMGA009797-TA; -.
DR   GeneID; 101739896; -.
DR   KEGG; bmor:101739896; -.
DR   eggNOG; KOG0493; Eukaryota.
DR   HOGENOM; CLU_051739_1_0_1; -.
DR   InParanoid; P27609; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Segmentation polarity protein.
FT   CHAIN           1..372
FT                   /note="Segmentation polarity homeobox protein engrailed"
FT                   /id="PRO_0000196076"
FT   DNA_BIND        280..339
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          47..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..282
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  41554 MW;  796B265E5B10BF27 CRC64;
     MAFEDRCSPS QANSPGPVTG RVPAPHAETL AYSPQSQYTC TTIESKYERG SPNMTIVKVQ
     PDSPPPSPGR GQNEMEYQDY YRPETPDVKP HFSREEQRFE LDRSRGQRLQ PTTPVAFSIN
     NILHPEFGLN AIRKTSKIEG PKPIGPNHSI LYKPYDLSKP DLSKYGFDYL KSKETSDCNA
     LPPLGGLRET VSQIGERLSR DREPPKSLEQ QKRPDSASSI VSSTSSGAVS TCGSSDASSI
     QSQSNPGQLW PAWVYCTRYS DRPSSGPRSR RVKKKAAPEE KRPRTAFSGA QLARLKHEFA
     ENRYLTERRR QSLAAELGLA EAQIKIWFQN KRAKIKKASG QRNPLALQLM AQGLYNHSTV
     TESDDEEEIN VT