ID   HMEN_HELTR              Reviewed;          98 AA.
AC   P23397;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Homeobox protein Ht-En;
DE   Flags: Fragment;
GN   Name=HT-EN;
OS   Helobdella triserialis (Leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1672111; DOI=10.1016/0014-5793(91)80172-y;
RA   Wedeen C.J., Price D.J., Weisblat D.A.;
RT   "Cloning and sequencing of a leech homolog to the Drosophila engrailed
RT   gene.";
RL   FEBS Lett. 279:300-302(1991).
CC   -!- FUNCTION: This protein specifies the body segmentation pattern.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- PTM: Phosphorylated in the Ser-rich domain. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; X58692; CAA41535.1; -; Genomic_DNA.
DR   PIR; S13623; S13623.
DR   AlphaFoldDB; P23397; -.
DR   SMR; P23397; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Segmentation polarity protein.
FT   CHAIN           <1..98
FT                   /note="Homeobox protein Ht-En"
FT                   /id="PRO_0000196085"
FT   DNA_BIND        3..62
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          79..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   98 AA;  11143 MW;  7BABA6CFAC56C698 CRC64;
     QDEKRPRTAF TGDQLARLKR EFSENKYLTE QRRTCLAKEL NLNESQIKIW FQNKRAKMKK
     ASGVKNQLAL QLMAQGLYNH SSSSSSSSSS SSSIFLLA