HMEN_LYMST
ID HMEN_LYMST Reviewed; 799 AA.
AC A9ZPC9;
DT 15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Homeobox protein engrailed {ECO:0000250|UniProtKB:P02836, ECO:0000312|EMBL:BAF96782.1};
DE AltName: Full=Lsten {ECO:0000303|PubMed:18443822};
GN Name=EN {ECO:0000250|UniProtKB:P02836};
OS Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Lymnaeidae; Lymnaea.
OX NCBI_TaxID=6523;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAF96782.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Mantle {ECO:0000269|PubMed:18443822};
RX PubMed=18443822; DOI=10.1007/s00427-008-0217-0;
RA Iijima M., Takeuchi T., Sarashina I., Endo K.;
RT "Expression patterns of engrailed and dpp in the gastropod Lymnaea
RT stagnalis.";
RL Dev. Genes Evol. 218:237-251(2008).
CC -!- FUNCTION: May be involved in shell and shell gland formation during
CC development. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the dorsal ectoderm of early gastrulae
CC in a band corresponding to the peripheral area of the presumptive shell
CC gland. Also expressed at four points along the posterior ectoderm. In
CC late gastrulae, it is predominantly expressed in the peripheral
CC ectoderm of the shell gland and in spots at the posterior end behind
CC the presumptive foot. Expressed in late trochophore larvae at four
CC points behind the foot, at two locations at the base of the foot and in
CC the peripheral ectoderm of the shell gland.
CC {ECO:0000269|PubMed:18443822}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryonic development in the
CC early and late gastrula stages, but not in the gastrulating blastula
CC stage. Also expressed in the late trochophore stage.
CC {ECO:0000269|PubMed:18443822}.
CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000255}.
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DR EMBL; AB331395; BAF96782.1; -; mRNA.
DR AlphaFoldDB; A9ZPC9; -.
DR SMR; A9ZPC9; -.
DR PRIDE; A9ZPC9; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF10525; Engrail_1_C_sig; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus.
FT CHAIN 1..799
FT /note="Homeobox protein engrailed"
FT /id="PRO_0000390387"
FT DNA_BIND 698..757
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 189..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 88245 MW; 4A9D5B12A63AA58D CRC64;
METIGFMKNI ETFAFPKQET VAMDDRAAAS NFLGQPPVGG PPVKDLSALK RPASEMVKSH
VGLFSPVKRR RHCGHSSVSD LARSASCVRS LAMKAKNTWM SNVPVMSSTH LVKRECPPVQ
GADLSDNLAT ASSPAHTGKG YTPFEDICLK QLLEVSRHKL FRSLEEVRGS DVRHDSRCDV
PRAVRCRSLP SRMTPEKNSA EVSIGGLKDQ SPSTSIRSNL VSSLLGVSRR DDQETSDSCH
DDDDDRAIND SERYDVSECD ESGPPTPSSG FIDIEADTPP CSPLNLTTTG GDSVSQLFHS
SGHGVGDRQR NTASTDAKSS HIKSKSEDAT KDKLGPCCCC GTTCSGGTCK EKKTNFSIDA
ILRPDFGSGN FLGQDGHTFQ PNEDHQTVSS AQTTPRFSSP DSAFKVVDLR TRSRSESLSS
PSSSSSSSRS SPSPPLTSPV SLRQKWERQT GSFMRRHLKG QEHFNFPQSL FPNPSKDLEN
FIGRDFPFIS PPQGNPLVKF PNIFPDQLSH LHPAMPAECV DPRTFYYAPE NFLSKGQQPL
LSYDMSKLFG RSLHPFLNSP PKPQPQKRPG HHLAPTPVEG VTLKSVGTNH NPKVLPEVKT
PVQSPQGDQK KRSRDESASK GKQVADQNVH LKENSQKSDP VLKQEKGNRK VSPAGASPET
DKAKNPLWPA WVFCTRYSDR PSSGPRSRKP KRSKAQDEKR PRTAFTNDQL QRLKREFDEC
RYLTETRRKN LADELGLTES QIKIWFQNKR AKIKKSVGVR NPLALQLMEQ GLYNHSTIKE
MMEEGMYPHT PSQAGDDSS
