ID   HMEN_SCHAM              Reviewed;          93 AA.
AC   P14150;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Segmentation polarity homeobox protein engrailed;
DE            Short=G-EN;
DE   Flags: Fragment;
GN   Name=en;
OS   Schistocerca americana (American grasshopper).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2570637; DOI=10.1016/0092-8674(89)90947-1;
RA   Patel N.H., Martin-Blanco E., Coleman K.G., Poole S.J., Ellis M.C.,
RA   Kornberg T.B., Goodman C.S.;
RT   "Expression of engrailed proteins in arthropods, annelids, and chordates.";
RL   Cell 58:955-968(1989).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; M29262; AAA29807.1; -; mRNA.
DR   PIR; A32994; A32994.
DR   AlphaFoldDB; P14150; -.
DR   SMR; P14150; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..>93
FT                   /note="Segmentation polarity homeobox protein engrailed"
FT                   /id="PRO_0000196079"
FT   DNA_BIND        34..93
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          12..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         93
SQ   SEQUENCE   93 AA;  11188 MW;  036AFA3C1A6F657B CRC64;
     LWPAWVYCTR YSDGPSSGRS PRSRRLKRNK KPEEKRPRTA FSGEQLARLK HEFTENRYLT
     ERRRQELARE LGLNEAQIKI WFQNKRAKIK KAS