ID   HMEN_TRIGR              Reviewed;         154 AA.
AC   P09532;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Homeobox protein engrailed;
DE   AltName: Full=SU-HB-En;
DE   Flags: Fragment;
GN   Name=EN;
OS   Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Tripneustes.
OX   NCBI_TaxID=7673;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Dolecki G.J.;
RL   Submitted (JUL-1988) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-154.
RX   PubMed=2899533; DOI=10.1016/0378-1119(88)90477-5;
RA   Dolecki G.J., Humphreys T.;
RT   "An engrailed class homeo box gene in sea urchins.";
RL   Gene 64:21-31(1988).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; M19709; AAA30090.1; -; Genomic_DNA.
DR   PIR; JT0287; JT0287.
DR   AlphaFoldDB; P09532; -.
DR   SMR; P09532; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..154
FT                   /note="Homeobox protein engrailed"
FT                   /id="PRO_0000196090"
FT   DNA_BIND        37..96
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          127..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   154 AA;  17708 MW;  FE0D2285AE438F5C CRC64;
     NSGYSNIHNE MLFDFVVFVF TGPRTRKVKR REKKADEKRP RTAFSASQLQ RLKQEFQQSN
     YLTEQRRRSL AKELTLSESQ IKIWFQNKRA KIKKASGLKN DLARQLMAQG LYNHSTVPLE
     ADSMDTKLLN GQNTSGDCSR SDYTSDSDGD SLTH