HMG10_ARATH
ID HMG10_ARATH Reviewed; 319 AA.
AC Q9LTT3;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=High mobility group B protein 10;
DE AltName: Full=Nucleosome/chromatin assembly factor group D 10;
GN Name=HMGB10; Synonyms=ARID-HMG2, NFD10; OrderedLocusNames=At3g13350;
GN ORFNames=MDC11.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=19053246; DOI=10.1021/bi801772k;
RA Hansen F.T., Madsen C.K., Nordland A.M., Grasser M., Merkle T.,
RA Grasser K.D.;
RT "A novel family of plant DNA-binding proteins containing both HMG-box and
RT AT-rich interaction domains.";
RL Biochemistry 47:13207-13214(2008).
CC -!- FUNCTION: Binds preferentially DNA with A/T-rich content.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9LTT3; Q9LG02: HMGB11; NbExp=3; IntAct=EBI-4473135, EBI-15201560;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:19053246}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:19053246}.
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DR EMBL; AB024034; BAB02804.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75337.1; -; Genomic_DNA.
DR EMBL; AF361582; AAK32750.1; -; mRNA.
DR EMBL; AY133557; AAM91387.1; -; mRNA.
DR EMBL; AY087770; AAM65306.1; -; mRNA.
DR RefSeq; NP_566454.1; NM_112180.4.
DR AlphaFoldDB; Q9LTT3; -.
DR SMR; Q9LTT3; -.
DR BioGRID; 5869; 8.
DR IntAct; Q9LTT3; 8.
DR STRING; 3702.AT3G13350.1; -.
DR iPTMnet; Q9LTT3; -.
DR PaxDb; Q9LTT3; -.
DR PRIDE; Q9LTT3; -.
DR ProteomicsDB; 228803; -.
DR EnsemblPlants; AT3G13350.1; AT3G13350.1; AT3G13350.
DR GeneID; 820535; -.
DR Gramene; AT3G13350.1; AT3G13350.1; AT3G13350.
DR KEGG; ath:AT3G13350; -.
DR Araport; AT3G13350; -.
DR TAIR; locus:2088160; AT3G13350.
DR eggNOG; KOG0381; Eukaryota.
DR eggNOG; KOG2744; Eukaryota.
DR HOGENOM; CLU_035371_0_0_1; -.
DR InParanoid; Q9LTT3; -.
DR OMA; LYYGQER; -.
DR OrthoDB; 891562at2759; -.
DR PhylomeDB; Q9LTT3; -.
DR PRO; PR:Q9LTT3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LTT3; baseline and differential.
DR Genevisible; Q9LTT3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR CDD; cd16872; ARID_HMGB9-like; 1.
DR Gene3D; 1.10.150.60; -; 1.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR045303; ARID_HMGB9-like.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF46774; SSF46774; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..319
FT /note="High mobility group B protein 10"
FT /id="PRO_0000399935"
FT DOMAIN 40..131
FT /note="ARID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00355"
FT DNA_BIND 238..305
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 36296 MW; 7802A12A69F7456C CRC64;
MSTDISPPYS QTHVEPVNGY PSDNKRCDDS SVPAKYDDLV RNSALFWEKL RAFLGLTSKT
LKVPTVGGNT LDLHRLFIEV TSRGGIERVV KDRKWKEVIG AFSFPTTITS ASFVLRKYYL
KFLFQLEHVY YLEKPVSSLQ STDEALKSLA NESPNPEEGI DEPQVGYEVQ GFIDGKFDSG
YLVTMKLGSQ ELKGVLYHIP QTPSQSQQTM ETPSAIVQSS QRRHRKKSKL AVVDTQKPKC
HRSGYNFFFA EQYARLKPEY HGQERSITKK IGHMWSNLTE SEKQVYQDKG VKDVERYRIE
MLEYKSSHES GATASTVAQ
