HMG12_ARATH
ID HMG12_ARATH Reviewed; 149 AA.
AC Q941D1; Q3E975;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=High mobility group B protein 12;
DE AltName: Full=Nucleosome/chromatin assembly factor group D 12;
GN Name=HMGB12; Synonyms=NFD12; OrderedLocusNames=At5g23405; ORFNames=K19M13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q941D1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q941D1-2; Sequence=VSP_039945;
CC -!- SIMILARITY: Belongs to the HMGB family. {ECO:0000305}.
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DR EMBL; AB018110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93161.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93162.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70885.1; -; Genomic_DNA.
DR EMBL; AY052244; AAK97714.1; -; mRNA.
DR EMBL; BT020349; AAV85704.1; -; mRNA.
DR RefSeq; NP_001318627.1; NM_001343801.1. [Q941D1-2]
DR RefSeq; NP_568430.2; NM_122247.2. [Q941D1-2]
DR RefSeq; NP_851063.1; NM_180732.2. [Q941D1-1]
DR AlphaFoldDB; Q941D1; -.
DR SMR; Q941D1; -.
DR BioGRID; 17681; 3.
DR IntAct; Q941D1; 4.
DR STRING; 3702.AT5G23405.1; -.
DR PaxDb; Q941D1; -.
DR PRIDE; Q941D1; -.
DR ProteomicsDB; 232098; -. [Q941D1-1]
DR EnsemblPlants; AT5G23405.1; AT5G23405.1; AT5G23405. [Q941D1-1]
DR EnsemblPlants; AT5G23405.2; AT5G23405.2; AT5G23405. [Q941D1-2]
DR EnsemblPlants; AT5G23405.3; AT5G23405.3; AT5G23405. [Q941D1-2]
DR GeneID; 832406; -.
DR Gramene; AT5G23405.1; AT5G23405.1; AT5G23405. [Q941D1-1]
DR Gramene; AT5G23405.2; AT5G23405.2; AT5G23405. [Q941D1-2]
DR Gramene; AT5G23405.3; AT5G23405.3; AT5G23405. [Q941D1-2]
DR KEGG; ath:AT5G23405; -.
DR Araport; AT5G23405; -.
DR TAIR; locus:505006631; AT5G23405.
DR eggNOG; KOG0381; Eukaryota.
DR HOGENOM; CLU_1761275_0_0_1; -.
DR InParanoid; Q941D1; -.
DR OMA; NGCQNGR; -.
DR OrthoDB; 1641977at2759; -.
DR PhylomeDB; Q941D1; -.
DR PRO; PR:Q941D1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q941D1; baseline and differential.
DR Genevisible; Q941D1; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0010197; P:polar nucleus fusion; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..149
FT /note="High mobility group B protein 12"
FT /id="PRO_0000399937"
FT DNA_BIND 63..131
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 111..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..149
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 43
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039945"
SQ SEQUENCE 149 AA; 17015 MW; ED7F213CF82D26AF CRC64;
MSGASSEDSS IFARCEDVDC NKKIPVELVR MHICYAMFHR TLAARGFGTQ TQAKKKPTNK
KKSTTSLTDF AVFMNHFRKS FRTDYNGALV KEGSKIGWEM WKSMTEDEKK DYLDKAADEE
DEDEDTVEEQ ADDSDDAEDN EVKETDDDN
