HMG12_CAEEL
ID HMG12_CAEEL Reviewed; 235 AA.
AC Q09390; O77096;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2002, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=High mobility group protein 1.2;
GN Name=hmg-1.2; ORFNames=F47D12.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RC STRAIN=Bristol N2;
RA Kurz T., Schulze E.;
RT "The high mobility group proteins of Caenorhabditis elegans.";
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- INTERACTION:
CC Q09390; G5EBR0: lir-1; NbExp=3; IntAct=EBI-2414021, EBI-320910;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q09390-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q09390-2; Sequence=VSP_002189;
CC Name=c;
CC IsoId=Q09390-3; Sequence=VSP_002190;
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DR EMBL; AF056577; AAC78599.1; -; mRNA.
DR EMBL; FO080618; CCD83369.1; -; Genomic_DNA.
DR EMBL; FO080618; CCD83370.1; -; Genomic_DNA.
DR EMBL; FO080618; CCD83371.1; -; Genomic_DNA.
DR PIR; T43009; T43009.
DR RefSeq; NP_001022599.1; NM_001027428.3. [Q09390-2]
DR RefSeq; NP_001022600.1; NM_001027429.4.
DR RefSeq; NP_498375.1; NM_065974.7. [Q09390-1]
DR AlphaFoldDB; Q09390; -.
DR SMR; Q09390; -.
DR BioGRID; 41110; 37.
DR IntAct; Q09390; 4.
DR STRING; 6239.F47D12.4a.1; -.
DR EPD; Q09390; -.
DR PaxDb; Q09390; -.
DR PeptideAtlas; Q09390; -.
DR EnsemblMetazoa; F47D12.4a.1; F47D12.4a.1; WBGene00001972. [Q09390-1]
DR EnsemblMetazoa; F47D12.4b.1; F47D12.4b.1; WBGene00001972. [Q09390-2]
DR EnsemblMetazoa; F47D12.4c.1; F47D12.4c.1; WBGene00001972. [Q09390-3]
DR GeneID; 175890; -.
DR KEGG; cel:CELE_F47D12.4; -.
DR UCSC; F47D12.4a.1; c. elegans. [Q09390-1]
DR CTD; 175890; -.
DR WormBase; F47D12.4a; CE26923; WBGene00001972; hmg-1.2. [Q09390-1]
DR WormBase; F47D12.4b; CE28233; WBGene00001972; hmg-1.2. [Q09390-2]
DR WormBase; F47D12.4c; CE28234; WBGene00001972; hmg-1.2. [Q09390-3]
DR eggNOG; KOG0381; Eukaryota.
DR GeneTree; ENSGT00940000153299; -.
DR InParanoid; Q09390; -.
DR OMA; EMRNYKG; -.
DR OrthoDB; 1641977at2759; -.
DR PhylomeDB; Q09390; -.
DR Reactome; R-CEL-140342; Apoptosis induced DNA fragmentation.
DR Reactome; R-CEL-163282; Mitochondrial transcription initiation.
DR Reactome; R-CEL-5620971; Pyroptosis.
DR Reactome; R-CEL-5686938; Regulation of TLR by endogenous ligand.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR SignaLink; Q09390; -.
DR PRO; PR:Q09390; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001972; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:WormBase.
DR GO; GO:0001708; P:cell fate specification; IMP:WormBase.
DR GO; GO:0008406; P:gonad development; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0040025; P:vulval development; IMP:WormBase.
DR GO; GO:0016055; P:Wnt signaling pathway; IGI:WormBase.
DR Gene3D; 1.10.30.10; -; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; SSF47095; 2.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..235
FT /note="High mobility group protein 1.2"
FT /id="PRO_0000048602"
FT DNA_BIND 47..117
FT /note="HMG box 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 135..203
FT /note="HMG box 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 25
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_002189"
FT VAR_SEQ 111..112
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_002190"
SQ SEQUENCE 235 AA; 27320 MW; 5C5BA447E4259B67 CRC64;
MNSGYSANIF PSSSSPTLYQ SHQLQPNPSA TMYQATPRDM GKPPVRGKTS PYGFFVKMCY
EEHKKKYPNE NVQVTEISKK CSEKWKTMVD DEKRRFYELA QKDAERYQAE VSVAAYGGED
AMRKRKRAKK DPHAPKRALS AFFFYSQDKR PEIQAGHPDW KVGQVAQELG KMWKLVPQET
KDMYEQKAQA DKDRYADEMR NYKAEMQKMS GMDHYDDDNI HHVVHVEDIN SQNIS
