ID   HMGB4_BOVIN             Reviewed;         194 AA.
AC   Q32L34;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=High mobility group protein B4;
GN   Name=HMGB4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6P8W9}.
CC       Chromosome {ECO:0000250|UniProtKB:Q6P8W9}. Note=Interacts specifically
CC       with the sex chromosomes. {ECO:0000250|UniProtKB:Q6P8W9}.
CC   -!- SIMILARITY: Belongs to the HMGB family. {ECO:0000305}.
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DR   EMBL; BC109790; AAI09791.1; -; mRNA.
DR   RefSeq; NP_001035652.1; NM_001040562.3.
DR   AlphaFoldDB; Q32L34; -.
DR   SMR; Q32L34; -.
DR   STRING; 9913.ENSBTAP00000000438; -.
DR   PaxDb; Q32L34; -.
DR   PRIDE; Q32L34; -.
DR   Ensembl; ENSBTAT00000000438; ENSBTAP00000000438; ENSBTAG00000000335.
DR   GeneID; 539195; -.
DR   KEGG; bta:539195; -.
DR   CTD; 127540; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000335; -.
DR   VGNC; VGNC:29876; HMGB4.
DR   eggNOG; KOG0381; Eukaryota.
DR   GeneTree; ENSGT00940000162735; -.
DR   HOGENOM; CLU_082854_0_4_1; -.
DR   InParanoid; Q32L34; -.
DR   OMA; KMWSAKT; -.
DR   OrthoDB; 1641977at2759; -.
DR   TreeFam; TF105371; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000000335; Expressed in semen and 15 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 2.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   SMART; SM00398; HMG; 2.
DR   SUPFAM; SSF47095; SSF47095; 2.
DR   PROSITE; PS50118; HMG_BOX_2; 2.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..194
FT                   /note="High mobility group protein B4"
FT                   /id="PRO_0000269179"
FT   DNA_BIND        9..79
FT                   /note="HMG box 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        93..161
FT                   /note="HMG box 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   194 AA;  23021 MW;  51A8DC1EA52A9FC1 CRC64;
     MGKRDQLKPK ANVSSYIHFL LNYRNKFKEQ QPNTYLGFKE FSRKCSEKWR SISKHEKAKY
     EALAKLDKAR YQEEMMNYFG RRKKRRKRDP HAPRRPPSSF LLFCQDHYAQ LKSENPSWSV
     VQVAKASGKM WSAKTDVDKQ PYEQRAALLR AKYREELSVY RNQFNARKTC LQESATNQCR
     EFEQAESDTT DGSN